5 datasets found
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Federal
Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis
U.S. Department of Health & Human Services —
Proteinase-3 (PR-3) is a neutral serine proteinase present in azurophil granules of human polymorphonuclear leukocytes and serves as the major target antigen of... -
Federal
What you should know about PR3-ANCA: Conformational requirements of proteinase 3 (PR3) for enzymatic activity and recognition by PR3-ANCA
U.S. Department of Health & Human Services —
The neutrophil azurophil granule constituent proteinase 3 (PR3) is the principal antigen for anti-neutrophil cytoplasmic antibodies (ANCA) in Wegener's... -
Federal
What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)
U.S. Department of Health & Human Services —
Reactive antigenic epitopes on presumed autoantigens of biologic interest have been examined by many researchers. The central third complementarity-determining region... -
Federal
What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis
U.S. Department of Health & Human Services —
The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the... -
Federal
Research Article: Arthritis Research
U.S. Department of Health & Human Services —
Wegener's granulomatosis (WG) is a form of systemic vasculitis. It is characterized by granulomatous inflammation in the upper and lower airways, vasculitis and...
5 datasets found