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Federal
Using ToxCast data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure.
U.S. Environmental Protection Agency —
Background: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological... -
Federal
Computational Modeling and Simulation of Genital Tubercle Development
U.S. Environmental Protection Agency —
Hypospadias is a developmental defect of urethral tube closure that has a complex etiology involving genetic and environmental factors, including anti-androgenic and... -
Federal
Estimating Hepatotoxic Doses Using High-content Imaging in Primary Hepatocytes
U.S. Environmental Protection Agency —
This repository contains the necessary data, python source code and jupyter notebooks to reproduce the results from our manuscript, "Estimating Hepatotoxic Doses... -
Federal
Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes
U.S. Environmental Protection Agency —
Background: Trends in male reproductive health have been reported for increased rates of testicular germ cell tumors, low semen quality, cryptorchidism, and...