42 datasets found
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Federal
Extracting and benchmarking emerging adverse outcome pathway knowledge
U.S. Environmental Protection Agency —
A collection of R scripts useful for extracting and analyzing adverse outcome pathway network data from the adverse outcome pathway wiki (aopwiki.org). This dataset... -
Federal
Conversion of environmental estrone to estradiol by male fathead minnows
U.S. Environmental Protection Agency —
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations... -
Federal
Weight of evidence evaluation of a network of adverse outcome pathways linking activaiton of the nicotinic acetylcholine receptor in honey bees to colony death
U.S. Environmental Protection Agency —
Ongoing honey bee colony losses are of significant international concern because of the essential role these insects play in pollinating many high nutrient crops,... -
Federal
Male Fathead Minnow Transcriptomes and Associated Chemical Analytes in Milwaukee Estuary System
U.S. Environmental Protection Agency —
This dataset presents the full hepatic transcriptomes of fathead minnows (Pimephales promelas) caged for four days at multiple sites within the Milwaukee Estuary area... -
Federal
An Integrated Approach for Identifying Priority Contaminant in the Great Lakes Basin –Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary Areas of Concern
U.S. Environmental Protection Agency —
Prioritization of chemicals was performed on two Areas of Concerns in the Great Lakes An integrated risk surveillance and monitoring approach was applied Bio-effect... -
Federal
Advancing the Adverse Outcome Pathway Concept – An International ‘Horizon Scanning’ Approach
U.S. Environmental Protection Agency —
Our ability to conduct whole organism toxicity tests to understand chemical safety has been outpaced by our ability to synthesize new chemicals for a wide variety of... -
Federal
Identifying chemicals and mixtures of potential biological concern detected in passive samplers from Great Lakes tributaries using high-throughput data and biological pathways
U.S. Environmental Protection Agency —
Water-borne contaminants were monitored in 69 tributaries of the Laurentian Great Lakes in 2010 and 2014 using semipermeable membrane devices (SPMDs), and polar... -
Federal
Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17beta-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas).
U.S. Environmental Protection Agency —
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and... -
Federal
Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay
U.S. Environmental Protection Agency —
The present study describes pilot testing of a high throughput compatible transcriptomics assay with larval fathead minnows. One day post hatch fathead minnows were... -
Federal
Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development
U.S. Environmental Protection Agency —
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations... -
Federal
Potential toxicity of complex mixtures in surface waters from a nationwide survey of United States streams: Identifying in vitro bioactivities and causative chemicals
U.S. Environmental Protection Agency —
In vitro biological activity data from a extracts of a nationwide survey of US streams. This dataset is associated with the following publication: Blackwell, B., G.... -
Federal
Gene transcription ontogeny of hypothalamic-pituitary-thyroid axis development in early-life stage fathead minnow and zebrafish
U.S. Environmental Protection Agency —
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to... -
Federal
Data from "A method for CRISPR/Cas9 mutation of genes in fathead minnow (Pimephales promelas)"
U.S. Environmental Protection Agency —
The dataset includes survival of control, control injected, and CRISPR/Cas9 injected embryos as well as percent efficiency of insertion/deletion mutation formation... -
Federal
Maumee River 2012 and 2016
U.S. Environmental Protection Agency —
The Maumee River and associated tributaries are an example of a system influenced by a mosaic of contaminant inputs from point and nonpoint sources along a gradient... -
Federal
Bioactive Contaminants of Emerging Concern in National Park Waters of the Northern Colorado Plateau, USA
U.S. Environmental Protection Agency —
Water and sediment was collected to assess the occurrence of contaminants of emerging concern (CECs) in National Park waters of the northern Colorado Plateau, USA.... -
Federal
Quantitative response-response relationships linking aromatase inhibition to decreased fecundity are conserved across three fishes with asynchronous oocyte development
U.S. Environmental Protection Agency —
Data used in the creation of each figure and table cited in Doering et al. (2019; DOI: 10.1021/acs.est.9b02606) are provided. This dataset is associated with the... -
Federal
Toward an AOP Network-based tiered testing strategy for the assessment of thyroid hormone disruption
U.S. Environmental Protection Agency —
No novel data were reported in association with this product. This dataset is not publicly accessible because: The associated publication is a review/forum-type... -
Federal
Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA
U.S. Environmental Protection Agency —
The datafile contains data associated with analytical chemistry, fish gene expression, in vitro bioassays, chemical prioritization, and Attagene data for surface... -
Federal
Derivation and Evaluation of Putative Adverse Outcome Pathways for Effects of Cycylooxygenase inhibitors on Reproductive Processes in Female Fish
U.S. Environmental Protection Agency —
Fathead minnows (Pimephales promelas) were exposed to 100 ug/L indomethacin, 200 ug/L ibuprofen, or 20 ug/L celecoxib for 96 h. Effects on cycloxygenase enzyme... -
Federal
First Generation Annotations for the Fathead Minnow (Pimephales promelas) Genome
U.S. Environmental Protection Agency —
The fathead minnow (Pimephales promelas) is a laboratory model organism widely used in regulatory toxicity testing and ecotoxicology research. Despite, the wealth of...
42 datasets found