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4 datasets found

Federal

Articular cartilage and changes in Arthritis: Collagen of articular cartilage

U.S. Department of Health & Human Services —

The extracellular framework and two-thirds of the dry mass of adult articular cartilage are polymeric collagen. Type II collagen is the principal molecular component...
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Federal

Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

U.S. Department of Health & Human Services —

Recent work has established that IL-1β plays a central role in the inflammation and connective tissue destruction observed in both rheumatoid arthritis and...
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Federal

What can we do about osteoarthritis?

U.S. Department of Health & Human Services —

Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be...
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Federal

Production of interleukin-1 receptor antagonist by human articular chondrocytes

U.S. Department of Health & Human Services —

Interleukin-1 receptor antagonist (IL-1Ra) is a natural IL-1 inhibitor possessing anti-inflammatory properties. IL-1Ra is produced as different isoforms, one secreted...
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4 datasets found

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