27 datasets found
-
Federal
Ammonium Perchlorate - Serum dosimetry, neurotoxicity and resilience of the neonatal rat thyroid system
U.S. Environmental Protection Agency —
Perchlorate is an environmental contaminant that interferes with iodine uptake via the NIS transporter into the thyroid gland, reducing thyroid hormone (TH)... -
Federal
Raw Data for Jarema et al, 2022 Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish...
U.S. Environmental Protection Agency —
The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/toxics10050256/s1. Figure S1, Effect of DMSO on Light/Dark Locomotor... -
Federal
Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents
U.S. Environmental Protection Agency —
Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the... -
Federal
An ontology for developmental processes and toxicities of neural tube closure
U.S. Environmental Protection Agency —
The systems map described in this manuscript for neurulation will set the stage for constructing mathematical models and computer simulation of neural tube closure... -
Federal
Data for Brown et al MEA Developmental Neurotoxicity Screening Manuscript
U.S. Environmental Protection Agency —
These data are the individual parameter and well-level data that were support the conclusions in Brown et al. Note: the parameters CVtime and CVnetwork were not used.... -
Federal
Data for "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain"
U.S. Environmental Protection Agency —
Raw data accompanying "Thyroid Hormone Action Controls Multiple Components of Cell Junctions at the Ventricular Zone in the Newborn Rat Brain". This dataset is... -
Federal
Provides an overview of the analysis and associated files, scripts and datasets
U.S. Environmental Protection Agency —
This dataset contains the files, scripts and data that were used to run the simulations and data analyses for the manuscript. This dataset is associated with the... -
Federal
Dataset for Chemical Signatures of neurodevelopmental disorders
U.S. Environmental Protection Agency —
This dataset contains the data, code and associated files for the manuscript Authored by Marable et al. This dataset is associated with the following publication:... -
Federal
MEA 86 Compound data
U.S. Environmental Protection Agency —
This data file contains the full raw parameter data for the 86 compounds tested in the developmental MEA assay, as well as Area Under the Curve (AUC) calculations and... -
Federal
Moser_NTT_52:2015
U.S. Environmental Protection Agency —
data supporting manuscript figures. This dataset is associated with the following publication: Moser , V.C., P. Phillips , J. Hedge , and K. Mcdaniel.... -
Federal
Methods for Thyroid Hormone Measurements in Neonatal Rat Brain
U.S. Environmental Protection Agency —
Serum and brain thyroid hormone measurements in rat brain. This dataset is associated with the following publication: Gilbert, M., J. Ford, C. Riutta, K.... -
Federal
Thyroid Hormone Insufficiency Alters the Pattern of Expression of the Ca2+-Binding Proteins in the Rat Neonatal Cortex
U.S. Environmental Protection Agency —
Dataset includes various results from two studies: the first study being a pilot study (M1123) and the second including dose response (M1224). In both studies,... -
Federal
Data for Tipping Point determinations
U.S. Environmental Protection Agency —
The attached zip file contains all of the source data, intermediate outputs and R-scripts used to calculate the tipping points reported in the Frank et al manuscript.... -
Federal
A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays
U.S. Environmental Protection Agency —
Supplementary data for "A comparative study of biostatistical pipelines for benchmark concentration modeling of in vitro screening assays". This dataset is associated... -
Federal
Evaluation of Per- and Polyfluoroalkyl Substances (PFAS) In Vitro Toxicity Testing for Developmental Neurotoxicity
U.S. Environmental Protection Agency —
R-language data files from "Carstens KE, Freudenrich T, Wallace K, Choo S, Carpenter A, Smeltz M, Clifton MS, Henderson WM, Richard AM, Patlewicz G, Wetmore BA, Paul... -
Federal
Probabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network
U.S. Environmental Protection Agency —
Table of contents Table S1 DNT inventory List of sources and associated data collected for the development of the Bayesian hierarchical model. Table S2 Data... -
Federal
PBPK_modeloutputs_readme
U.S. Environmental Protection Agency —
Contains values from pbpk models for each study on n-butanol effects. This dataset is associated with the following publication: Segal, D., A. Bale, L. Phillips, A.... -
Federal
Iodine Deficiency Exacerbates Thyroidal and Neurological Effects of Developmental Perchlorate Exposure in the Neonatal and Adult Rat
U.S. Environmental Protection Agency —
Thyroid hormones status, brain molecular and structural changes, and neurobehavioral impairments following maternal exposure to perchlorate in a rodent pregnancy... -
Federal
Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
U.S. Environmental Protection Agency —
This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on...
27 datasets found