48 datasets found
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Federal
Aggregated Computational Toxicology Online Resource
U.S. Environmental Protection Agency —
Aggregated Computational Toxicology Online Resource (AcTOR) is EPA's online aggregator of all the public sources of chemical toxicity data. ACToR aggregates data from... -
Federal
MetaData_2025-01-27_Inhibition-of-Fin-Regeneration-in-Fathead-Minnow-(Pimephales-promelas)-by-a-Potent-Synthetic-Glucocorticoid-and-Development-of-Adverse-Outcome-Pathway-334
U.S. Environmental Protection Agency —
Metadata for both preliminary and definitive studies, including water quality parameters, experimental takedown data, fin measurements, and RT-PCR data. This dataset... -
Federal
Consumer Product Category Database
U.S. Environmental Protection Agency —
The Chemical and Product Categories database (CPCat) catalogs the use of over 40,000 chemicals and their presence in different consumer products. The chemical use... -
Federal
ToxCast Phase I
U.S. Environmental Protection Agency —
Background: Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use and the thousands of environmental... -
Federal
The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
U.S. Environmental Protection Agency —
The contents of the chemistry database, presently containing ~ 760,000 substances, are available as public domain data for download. The chemistry content... -
Federal
Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments
U.S. Environmental Protection Agency —
Dataset for Nyffeler et al., 'Application of Cell Painting for chemical hazard evaluation in support of screening-level chemical assessments', Toxicology &... -
Federal
Concentrations of Pesticides, Pharmaceuticals, Organic Waste Indicators, and Volatile Organic Chemical Contaminants and Their Predicted Effects Potential in Wadeable Southeastern USA Streams
Department of the Interior —
This dataset presents the results of 475 unique organic compounds collected from 54 wadeable streams within the Southeastern, USA, collected within 10 weeks during... -
Federal
Datasets associated with journal article 'Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example' by Nyffeler, J, et.al.
U.S. Environmental Protection Agency —
We evaluated the Templated Oligo with Sequencing Readout (TempO-Seq) assay for High-throughput transcriptomic screening of a small set of environmental chemicals.... -
Federal
Evaluation of 147 Perfluoroalkyl Substances for Immunosuppressive and other Activities Through Phenotypic Screening of Human Primary Cells
U.S. Environmental Protection Agency —
Dataset for journal article 'Evaluation of 147 Perfluoroalkyl Substances for Immunosuppressive and other Activities Through Phenotypic Screening of Human Primary... -
Federal
RJudson_Mansouri_CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity
U.S. Environmental Protection Agency —
Data and supplemental files from COMPARA (A large-scale modeling project). COMPARA combined multiple models developed in collaboration with modelers and computational... -
Federal
High-throughput screening of chemical effects on steroidogenesis using H295R human adrenocortical carcinoma cells
U.S. Environmental Protection Agency —
Disruption of steroidogenesis by environmental chemicals can result in altered hormone levels causing adverse reproductive and developmental effects. A high-... -
Federal
Chemical-Gene and Chemical-Pathway Interactions Predicted for Chemicals Detected in the USGS-USEPA National Streams Pilot Study Based on Effects Data in the Comparative Toxicogenomics Database (CTD)
Department of the Interior —
Data from study assessing the utility of knowledgebase-leveraging of comprehensive environmental-contaminant-exposure datasets by comparing biological effects... -
Federal
Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays
U.S. Environmental Protection Agency —
The data set contains data for the following assays performed using 6PPD-quinone and/or 6PPD. 1) Larval fathead minnow transcriptomics; 2) larval fathead minnow... -
Federal
SSDn insecticide dataset
U.S. Environmental Protection Agency —
This is a dataset of acute toxicity values for organophosphate and carbamate insecticides. the dataset is used to develop and validate the species sensitivity... -
Federal
Comparison of whole transcriptome and targeted RNA sequencing for ecological high-throughput transcriptomics
U.S. Environmental Protection Agency —
Supplementary data for "Comparison of whole transcriptome and targeted RNA sequencing for ecological high-throughput transcriptomics". This dataset is associated with... -
Federal
Pilot testing and optimization of a larval fathead minnow high throughput transcriptomics assay
U.S. Environmental Protection Agency —
The present study describes pilot testing of a high throughput compatible transcriptomics assay with larval fathead minnows. One day post hatch fathead minnows were... -
Federal
From Protein Sequence to Structure: The Next Frontier in Cross-Species Extrapolation for Chemical Safety Evaluations
U.S. Environmental Protection Agency —
Supplemental data for "LaLone CA, Blatz DJ, Jensen MA, Vliet SMF, Mayasich S, Mattingly KZ, Transue TR, Melendez W, Wilkinson A, Simmons CW, Ng C, Zhang C, Zhang Y.... -
Federal
Differentiating Pathway-Specific From Nonspecific Effects in High-Throughput Toxicity Data: A Foundation for Prioritizing Adverse Outcome Pathway Development
U.S. Environmental Protection Agency —
Previous work identified a ‘cytotoxic burst’ (CTB) phenomenon wherein large numbers of the ToxCast assays begin to respond at or near test chemical concentrations... -
Federal
Exposure Forecaster
U.S. Environmental Protection Agency —
The Exposure Forecaster Database (ExpoCastDB) is EPA's database for aggregating chemical exposure information and can be used to help with chemical exposure... -
Federal
Distributed Structure Searchable Toxicity
U.S. Environmental Protection Agency —
The Distributed Structure Searchable Toxicity (DSSTox) online resource provides high quality chemical structures and annotations in association with toxicity data. It...
48 datasets found