23 datasets found
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Federal
Black et al_human rat and trout CLint_ScienceHub entry
U.S. Environmental Protection Agency —
This dataset provides measured in vitro intrinsic clearance rates for 54 chemicals tested using isolated hepatocytes from humans, rats, and rainbow trout. The test... -
Federal
Reliability of in vitro methods used to measure intrinsic clearance of hydrophobic organic chemicals by fish: results of an international ring trial_Nichols et al._Science Hub entry_02232018
U.S. Environmental Protection Agency —
This paper describes the results of an international ring trial (round robin study) of in vitro methods used to measure chemical biotransformation in fish.... -
Federal
High-resolution Mass Spectrometry of Skin Mucus for Monitoring Physiological Impacts and Contaminant Biotransformation Products in Fathead Minnows Exposed to Wastewater Effluent
U.S. Environmental Protection Agency —
High-resolution mass spectrometry is advantageous for monitoring physiological impacts and contaminant biotransformation products in fish exposed to complex... -
Federal
Sex-Linked Changes in Biotransformation of Phenol in Brook Trout (Salvelinus fontinalis) over an Annual Reproductive Cycle
U.S. Environmental Protection Agency —
Dataset for "Kolanczyk, R.C.; Solem, L.E.; Tapper, M.A.; Hoffman, A.D.; Sheedy, B.R.; Schmieder, P.K.; McKim, J.M., III. Sex-Linked Changes in Biotransformation of... -
Federal
Dataset for In vitro-in vivo extrapolation of hepatic biotransformation data for fish. III. An in-depth case study with pyrene.
U.S. Environmental Protection Agency —
This dataset, presented as an Excel spreadsheet, contains all data presented as figures and tables in an article by Nichols et al, entitled "In vitro-in vivo... -
Federal
PFAS Biotransformation Pathways: A Species Comparison Study
U.S. Environmental Protection Agency —
Data for "Kolanczyk RC, Saley MR, Serrano JA, Daley SM, Tapper MA. PFAS Biotransformation Pathways: A Species Comparison Study. Toxics. 2023 Jan 12;11(1):74. doi:... -
Federal
Saunders et al_IVIVE paper_Science Hub_entry_08142020
U.S. Environmental Protection Agency —
The purpose of is this study was to evaluate the potential for biotransformation in the gastrointestinal tissues (GIT) of fish to impact chemical bioaccumulation. In... -
Federal
Measurement of kinetic parameters for biotransformation of PAHs by trout liver S9 fractions: Implications for bioaccumulation assessment
U.S. Environmental Protection Agency —
The dataset, which is presented as an Excel spreadsheet, contains all data which is presented as figures in Nichols et al., Measurement of kinetic parameters for... -
Federal
Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of Blood–Water Partitioning and Chemical Volume of Distribution
U.S. Environmental Protection Agency —
Supporting information in "Saunders, L.J. and Nichols, J.W. (2023), Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates... -
Federal
Category-Based Toxicokinetic Evaluations of Data-Poor Per- and Polyfluoroalkyl Substances (PFAS) using Gas Chromatography Coupled with Mass Spectrometry
U.S. Environmental Protection Agency —
Supplementary material for "Kreutz, A.; Clifton, M.S.; Henderson, W.M.; Smeltz, M.G.; Phillips, M.; Wambaugh, J.F.; Wetmore, B.A. Category-Based Toxicokinetic... -
Federal
Comparison of cryopreserved trout hepatocytes and liver S9 fractions as in vitro tools for bioaccumulation assessment of chemicals that undergo biotransformation in fish
U.S. Environmental Protection Agency —
The purpose of this study was to compare two in vitro systems, cryopreserved trout hepatocytes and trout liver S9 fractions, used to predict in vivo levels of... -
Federal
Non-Targeted Analysis (NTA) of Plasma and Liver from Sprague Dawley Rats Exposed to Perfluorohexanesulfonamide (PFHxSA), a Precursor to Perfluorohexane Sulfonic Acid (PFHxS)
U.S. Environmental Protection Agency —
Supplementary materials for "Non-Targeted Analysis (NTA) of Plasma and Liver from Sprague Dawley Rats Exposed to Perfluorohexanesulfonamide (PFHxSA), a Precursor to... -
Federal
Characterization data for trout liver S9 fractions used by Droge et al to measure the in vitro intrinsic clearance of cationic surfactants
U.S. Environmental Protection Agency —
This ScienceHub dataset provides characterization data for a pooled sample of trout liver S9 fractions that was used to study the in vitro intrinsic clearance of... -
Federal
Saunders et al._Dietary bioaccumulation and biotransformation of hydrophobic organic sunscreen agents in rainbow trout
U.S. Environmental Protection Agency —
Organic ultraviolet filters (UVFs; also known as sunscreen agents) used in personal care and consumer products can enter the aquatic environment via wastewater... -
Federal
Nichols et al._Biotransformation of PAH mixures by trout liver S9 fractions
U.S. Environmental Protection Agency —
This Excel spreadsheet provides data that appear in Tables 1- 2 and Figures 1-4 of the main document, as well as data that appear in Figures S1-S3 of the... -
Federal
Saunders et al. Amended IVIVE model
U.S. Environmental Protection Agency —
This paper described development of an in vitro/in vivo model that accounts for first pass clearance effects. The model details are contained in the supporting... -
Federal
Simmons_DeGroot_Metabolism_mRNA_transfection_ApplInVitroTox_Data
U.S. Environmental Protection Agency —
The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS)... -
Federal
Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation - data set
U.S. Environmental Protection Agency —
Data set to support the manuscript "Increased endocrine activity of xenobiotic chemicals as mediated by metabolic activation". Contains analytical measurement of... -
Federal
Allometric scaling of hepatic biotransformation in rainbow trout
U.S. Environmental Protection Agency —
This dataset illustrates relationships between body weight and hepatic phase I and phase II metabolic activity in rainbow trout. This dataset is associated with the... -
Federal
In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories
U.S. Environmental Protection Agency —
Dataset for "Crizer, D.M.; Rice, J.R.; Smeltz, M.G.; Lavrich, K.S.; Ravindra, K.; Wambaugh, J.F.; DeVito, M.; Wetmore, B.A. In Vitro Hepatic Clearance Evaluations of...
23 datasets found