15 datasets found
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Federal
Autoantibody profiling for the study and treatment of autoimmune disease
U.S. Department of Health & Human Services —
Proteomics technologies enable profiling of autoantibody responses using biological fluids derived from patients with autoimmune disease. They provide a powerful tool... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Clinical experience
U.S. Department of Health & Human Services —
In the past 5 years, around 350 patients have received haematopoietic stem cell (HSC) transplantation for an autoimmune disease, with 275 of these registered in an... -
Federal
Autologous stem-cell transplantation in refractory autoimmune diseases after
U.S. Department of Health & Human Services —
Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete... -
Federal
High frequency of association of rheumatic/autoimmune diseases and untreated male hypogonadism with severe testicular dysfunction
U.S. Department of Health & Human Services —
Our goal in the present work was to determine whether male patients with untreated hypogonadism have an increased risk of developing rheumatic/autoimmune disease... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation
U.S. Department of Health & Human Services —
Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Introduction
U.S. Department of Health & Human Services —
Immune ablation and stem-cell therapy in autoimmune disease: Introduction -
Federal
The potential of human regulatory T cells generated
U.S. Department of Health & Human Services —
Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self-reactive T cells. Contact-dependent CD4+ CD25+ 'professional'... -
Federal
Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes
U.S. Department of Health & Human Services —
The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be... -
Federal
The role of X-chromosome inactivation in female predisposition to autoimmunity
U.S. Department of Health & Human Services —
We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed... -
Federal
Where is biological therapy going?
U.S. Department of Health & Human Services —
The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets... -
Federal
Death, autoantigen modifications, and tolerance
U.S. Department of Health & Human Services —
Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Experimental basis for autologous stem-cell transplantation
U.S. Department of Health & Human Services —
Treatment of rats suffering from florid chronic progressive systemic arthritis or from chronic remitting/relapsing encephalomyelitis with autologous bone marrow... -
Federal
The human exosome: an autoantigenic complex of exoribonucleases in myositis and scleroderma
U.S. Department of Health & Human Services —
The anti-PM/Scl autoantibodies are known to characterize a subset of autoimmune patients with myositis, scleroderma (Scl), and the PM/Scl overlap syndrome. The major... -
Federal
T-cell-mediated control of autoimmunity
U.S. Department of Health & Human Services —
Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging... -
Federal
21st European Workshop for Rheumatology Research, Vienna, Austria, 1–4 March 2001
U.S. Department of Health & Human Services —
Major advances in technology now drive how we approach questions in immunology, particularly in analyzing complex data sets commonly encountered in genomics and...
15 datasets found