81 datasets found
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Federal
Results of a phase-I/II randomized, masked, placebo-controlled trial of recombinant human interleukin-11 (rhIL-11) in the treatment of subjects with active rheumatoid arthritis
U.S. Department of Health & Human Services —
Interleukin-11 (IL-11) is a pleiotropic cytokine that regulates the growth and development of hematopoietic stem cells and decreases the proinflammatory mediators of... -
Federal
Rheumatoid arthritis viewed using a headache paradigm
U.S. Department of Health & Human Services —
Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however,... -
Federal
Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate and its relation to clinical variables in inflammatory arthritis
U.S. Department of Health & Human Services —
Hypothalamic–pituitary–adrenal underactivity has been reported in rheumatoid arthritis (RA). This phenomenon has implications with regard to the pathogenesis and... -
Federal
Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion
U.S. Department of Health & Human Services —
Mast cell (MC) activation in the rheumatoid lesion provides numerous mediators that contribute to inflammatory and degradative processes, especially at sites of... -
Federal
Genetic epidemiology: Approaches to the genetic analysis of rheumatoid arthritis
U.S. Department of Health & Human Services —
The basis of susceptibility to rheumatoid arthritis (RA) is complex, comprising genetic and environmental susceptibility factors. We have reviewed the available... -
Federal
A multinational randomized, controlled, clinical trial of etoricoxib in the treatment of rheumatoid arthritis [ISRCTN25142273]
U.S. Department of Health & Human Services —
Background Etoricoxib is a highly selective COX-2 inhibitor which was evaluated for the treatment of rheumatoid arthritis (RA). Methods Double-blind, randomized,... -
Federal
Arthritis Research: the move to publish research articles in full online only
U.S. Department of Health & Human Services —
WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for... -
Federal
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
U.S. Department of Health & Human Services —
In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly... -
Federal
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes
U.S. Department of Health & Human Services —
The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental... -
Federal
Association of MHC and rheumatoid arthritis:HLA polymorphisms in phenotypic variants of rheumatoid arthritis
U.S. Department of Health & Human Services —
Genes in the human leukocyte antigen (HLA) region remain the most powerful disease risk genes in rheumatoid arthritis (RA). Several allelic variants of HLA-DRB1 genes... -
Federal
B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response
U.S. Department of Health & Human Services —
The influence of HLA DRB1 alleles on B-cell homeostasis was analyzed in 164 patients with rheumatoid arthritis (RA). The percentages of CD19+ B lymphocytes determined... -
Federal
Homing chemokines in rheumatoid arthritis
U.S. Department of Health & Human Services —
In about 20% of patients with rheumatoid arthritis, B and T lymphocytes recruited into the inflamed synovium are organized into complex microstructures, which... -
Federal
IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
U.S. Department of Health & Human Services —
The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo... -
Federal
Research Article: Arthritis Research
U.S. Department of Health & Human Services —
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major... -
Federal
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
U.S. Department of Health & Human Services —
Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the... -
Federal
A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg
U.S. Department of Health & Human Services —
In recent years, the effectiveness of anti-TNF therapy in treating rheumatoid arthritis (RA) has become apparent. While trials of IL-1 receptor antagonist in RA have... -
Federal
Mosaic chromosomal aberrations in synovial fibroblasts of patients with rheumatoid arthritis, osteoarthritis, and other inflammatory joint diseases
U.S. Department of Health & Human Services —
Chromosomal aberrations were comparatively assessed in nuclei extracted from synovial tissue, primary-culture (P-0) synovial cells, and early-passage synovial... -
Federal
Bone loss: Therapeutic approaches for preventing bone loss in inflammatory arthritis
U.S. Department of Health & Human Services —
Inflammatory arthritides are commonly characterized by localized and generalized bone loss. Localized bone loss in the form of joint erosions and periarticular... -
Federal
B cells in rheumatoid arthritis
U.S. Department of Health & Human Services —
Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of... -
Federal
Differential expression of the angiogenic Tie receptor family in arthritic and normal synovial tissue
U.S. Department of Health & Human Services —
Angiopoietins (Ang) are vascular endothelial cell-specific growth factors that play important roles principally during the later stages of angiogenesis. We have...
81 datasets found