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Obstructive sleep apnea and vascular disease
There is emerging evidence linking obstructive sleep apnea (OSA) to vascular disease, including hypertension. This relationship may be independent of co-morbidity, such as... -
Sildenafil (Viagra) for male erectile dysfunction: a meta-analysis of clinical trial reports
Background Evaluation of company clinical trial reports could provide information for meta-analysis at the commercial introduction of a new technology. Methods Clinical trial... -
The influence of age on the female/male ratio of treated incidence rates in depression
Background Poor data exist on the influence of psychosocial variables on the female/male ratio of depression because of the small number of cases and the resulting limited... -
Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports
Background This investigation was undertaken to describe patient perception and awareness of the polycystic ovary syndrome (PCOS), the most common cause of... -
Molecular phylogeny of Subtribe Artemisiinae (Asteraceae), including
Background Subtribe Artemisiinae of Tribe Anthemideae (Asteraceae) is composed of 18 largely Asian genera that include the sagebrushes and mugworts. The subtribe includes the... -
Genetic studies of the Roma (Gypsies): a review
Background Data provided by the social sciences as well as genetic research suggest that the 8-10 million Roma (Gypsies) who live in Europe today are best described as a... -
Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital.
Introduction Sildenafil (Viagra®) is one of the drugs used in the first line therapy of male erectile dysfunction (MED). We have recorded outcomes, adverse events and... -
The effectiveness of reducing the daily dose of finasteride in men with benign prostatic hyperplasia
Background Finasteride, a 5 alpha reductase inhibitor, is an established treatment for benign prostatic hyperplasia. The recommended dosage is 5 mg a day, however case reports... -
A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology
Background An association between mumps-measles-rubella (MMR) vaccination and the onset of symptoms typical of autism has recently been suggested. This has led to considerable... -
Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations
Background The use of low-dose aspirin has been reported to be associated with an increased risk of upper gastrointestinal complications (UGIC). The coating of aspirin has been... -
Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg
Background Meta-analysis usually restricts the information pooled, for instance using only randomised, double-blind, placebo-controlled trials. This neglects other types of high... -
NIH Research Portfolio Online Reporting Tools: Expenditures and Results (RePORTER)
Research projects funded by the National Institutes of Health (NIH), other DHHS Operating Divisions (ACF, AHRQ, CDC, FDA, HRSA), and the Department of Veterans Affairs. The... -
Acetaminophen toxicity: suicidal vs accidental
Introduction Acetaminophen toxicity, which can lead to hepatotoxicity, is a burden on our health care system and contributes significantly to intensive care unit admissions and... -
A new prototype of an electronic jet-ventilator and its humidification system
Background: Adequate humidification in long-term jet ventilation is a critical aspect in terms of clinical safety. Aim: To assess a prototype of an electronic jet-ventilator and... -
New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy products
Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium intake on... -
Kefir consumption does not alter plasma lipid levels or cholesterol fractional synthesis rates relative to milk in hyperlipidemic men: a randomized controlled trial [ISRCTN10820810]
Background Fermented milk products have been shown to affect serum cholesterol concentrations in humans. Kefir, a fermented milk product, has been traditionally consumed for its... -
Systematic review of the use of honey as a wound dressing
Objective To investigate topical honey in superficial burns and wounds though a systematic review of randomised controlled trials. Data sources Cochrane Library, MEDLINE,... -
Debate: "How low should LDL cholesterol be lowered?" Viewpoint: "It doesn't need to be very low"
The importance of low-density lipoprotein (LDL) control in the management of patients at high risk of cardiovascular events is unquestionable. The major statin trials have shown... -
Time course of muscle soreness following different types of exercise
Background Post-exercise muscle soreness is a dull, aching sensation that follows unaccustomed muscular exertion. Primarily on the basis of previous laboratory-based research on...
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