{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "Background\n          It is known that use of hormone replacement therapy (HRT) by postmenopausal women increases the risk of breast cancer.\n        \n        \n          Method\n          In this study, oestrogen receptor (ER)-\u03b1 expression is examined using standard immunoperoxidase technique.\n        \n        \n          Results\n          Normal breast samples of 11 Australian postmenopausal women have been included in the ER-\u03b1 study; the result showed a strong correlation (r2 = 0.80) between ER-\u03b1 expression in normal breast epithelial cells and body mass index (BMI) in normal women who currently use HRT.\n        \n        \n          Conclusion\n          This finding confirms that the possibility of increased risk of breast cancer associated with increased ER-\u03b1 expression in normal breast epithelial cells, in turn associated with high BMI and the use of HRT.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC57804/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/9i9f-mgix", "issued": "2025-07-14", "keyword": ["nih", "hormone-replacement-therapy", "breast-cancer-risk", "estrogen-receptor-alpha", "postmenopausal-women"], "landingPage": "https://healthdata.gov/d/9i9f-mgix", "modified": "2025-09-06", "programCode": ["009:035"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women"}