{"accessLevel": "public", "bureauCode": ["010:12"], "contactPoint": {"@type": "vcard:Contact", "fn": "Thierry M. Work", "hasEmail": "mailto:thierry_work@usgs.gov"}, "description": "In 2010, a mass mortality of pufferfish in Hawaii was dominated by Arothron hispidus showing aberrant neurological behaviors.  Using pathology, toxinology, and field surveys, we implicated a series of novel, polar, marine toxins as a likely cause of this mass mortality.  Our findings are striking in that 1) a marine toxin was associated with a kill of  a fish species that is, itself, toxic; 2) we provide a plausible mechanism to explain clinical signs of affected fish, and 3) this epizootic likely depleted puffer populations.  Whilst our data are compelling, we did not synthesize the toxin de-novo, we were unable to categorically prove that the polar toxins caused mortality or that they were metabolites of an undefined parent compound.   However, our approach does provides a template for marine fish kill investigations associated with marine toxins and inherent limitations of existing methods.  Our study also highlights the need for more rapid and cost-effective tools to identify new marine toxins, particularly small, highly polar molecules.", "distribution": [{"@type": "dcat:Distribution", "accessURL": "https://doi.org/10.5066/F7SQ8XM8", "description": "Landing page for access to the data", "format": "XML", "mediaType": "application/http", "title": "Digital Data"}, {"@type": "dcat:Distribution", "description": "The metadata original format", "downloadURL": "https://data.usgs.gov/datacatalog/metadata/USGS.58b44cdbe4b01ccd54fca839.xml", "format": "XML", "mediaType": "text/xml", "title": "Original Metadata"}], "identifier": "http://datainventory.doi.gov/id/dataset/USGS_58b44cdbe4b01ccd54fca839", "keyword": ["USGS:58b44cdbe4b01ccd54fca839", "mortality data", "Dereplication", "tetraodontidae", "virology", "pathology", "toxinology"], "modified": "2020-10-20T00:00:00Z", "publisher": {"@type": "org:Organization", "name": "U.S. Geological Survey"}, "spatial": "-176.57226562163, 17.098374046212, -150.20507812268, 28.805790119802", "theme": ["geospatial"], "title": "Puffer Mortality Data"}