{"@type": "dcat:Dataset", "accessLevel": "public", "bureauCode": ["009:25"], "contactPoint": {"@type": "vcard:Contact", "fn": "NIH", "hasEmail": "mailto:info@nih.gov"}, "description": "p53 performs a plethora of activities, which are directed towards\nthe maintenance of the genomic integrity and constitute its\nuniversal role as a tumor suppressor. 1000 to 10000 latent p53\nmolecules are permanently available in order to monitor DNA\nexchange processes in mitotically growing cells. After the\nintroduction of major DNA injuries the levels of\nposttranslationally modified p53 proteins rise, which in turn\ntranscriptionally signal transient cell cycle arrest or apoptotic\ncell death, depending on the extent of damage. Taken together,\np53 inhibits the manifestation of genomic instabilities at\ndifferent control levels both during naturally occurring metabolic\nprocesses and in response to genotoxic treatments.", "distribution": [{"@type": "dcat:Distribution", "description": "Visit the original government dataset for complete information, documentation, and data access.", "downloadURL": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC79672/", "mediaType": "text/html", "title": "Official Government Data Source"}], "identifier": "https://healthdata.gov/api/views/kvc4-6xuy", "issued": "2025-07-14", "keyword": ["nih", "p53-protein", "dna-repair", "tumor-suppression", "genomic-stability"], "landingPage": "https://healthdata.gov/d/kvc4-6xuy", "modified": "2025-09-06", "programCode": ["009:033"], "publisher": {"@type": "org:Organization", "name": "National Institutes of Health"}, "theme": ["NIH"], "title": "Genetic stabilization by p53 involves growth regulatory and repair pathways"}