An integral part of disaster risk management is identifying and prioritizing hazards and their potential impacts in a meaningful way to support risk-reduction planning. There has been considerable use and subsequent criticism of threat prioritization efforts that simply compare likelihoods and consequences of plausible threats. This data supports an article that summarizes a new mixed-methods and scalable approach for prioritizing risks in a multi-hazard, multi-objective, and multi-criteria organizational context. This data describes (1) hazard characterizations using subject-matter-expert (SME) elicitation, (2) expressed preferences in planning priorities provided by emergency managers, and (3) quantitative estimates of asset exposure to hazards using geospatial data and geographic-information-systems (GIS) software. This data was derived from a case study designed to support multi-hazard mitigation and response planning done by the U.S. Department of the Interior (DOI) Office of Emergency Management, which required a national understanding of the risks posed by 75 different various natural, technological, and adversarial hazards to DOI lands, facilities, people, revenues, and resources.