These profiles of suspended-sediment concentration were collected and compiled to characterize suspended sediment in the Colorado River during both average flow conditions and during a controlled flood that occurred in March 2008. The objectives of the study were to measure changes in suspended sediment that occurred during changes in discharge associated with the controlled flood. These data were collected between March 4 and March 10, 2008 in the center of the channel 44.64 river miles downstream from Lees Ferry, Arizona on the Colorado River within Grand Canyon National Park. The sampling location was within a 1-mile study reach beginning 0.14 miles upstream from the sampling location. These data were collected by the USGS Grand Canyon Monitoring and Research Center with cooperators from Northern Arizona University and funding provided by the Glen Canyon Dam Adaptive Management Program. All samples were collected with USGS P-61 point integrating sampler. Samples were processed for silt and clay concentration, sand concentration, and sand grain size using standard methods. These data can be used to study suspended sediment concentration, which can be used in predictions of sediment transport and can be used to develop, calibrate, and verify transport models.