The Mofete and San Vito geothermal fields, located west of Naples, Italy, are part of the Campi Flegrei volcanic complex. A joint venture in the 1970s between AGIP and ENEL, the Italian National electric and petroleum utilities, respectively, drilled exploratory wells to a depth of ~3000 m in an attempt to locate high-enthalpy fluids for potential power production. Drill core samples from Mofete wells (MF1, MF2, and MF5) and from San Vito wells (SV1 and SV3) contain authigenic ore mineralization. Pyrite, pyrrhotite, and galena are abundant. Less common are chalcopyrite, sphalerite, arsenopyrite, scheelite, and rare are millerite, violarite, native bismuth, tellurobismuthite, cassiterite, molybdenite, and acanthite. Mineral chemistry was determined by electron microprobe wavelength dispersive spectroscopy aided by scanning electron microscope equipped with energy-dispersive spectroscopy. The mineral assemblage suggests a low sulfidation environment and the absence of pyrrhotite in the MF1 well and upper part of the SV1 well indicates variable sulfur activity. Scheelite in the SV3 well is zoned with variable Mo6+ content; low Mo6+ zones show blue cathodoluminescence, whereas, zones with high Mo6+ content are yellow to brown.