This data release contains input and output data from hydrologic simulations of naturalized or near-native streamflow conditions in the Upper Rio Grande Basin (URGB) in Colorado, New Mexico, Texas, and northern Mexico by using the Precipitation-Runoff Modeling System (PRMS). The Upper Rio Grande Basin PRMS model was calibrated in a three step process by (1) calibrating solar radiation and potential evapotranspiration parameters by subarea for hydrologic response units (HRU) in the model domain, (2) calibrating streamflow parameters in nine subbasins identified to be “near-native” subbasins, or basins with low anthropogenic disturbance, and (3) distributing calibrated parameters from near-native subbasins to uncalibrated HRUs in the model domain. The data release contains the pre- and post-calibrated input and output data, for each of the three steps, needed to run PRMS to achieve the results presented in a U.S. Geological Survey Scientific Investigations Report (Chavarria and others, 2020).