In May 2021, the Grand Canyon Monitoring and Research Center (GCMRC) of the U.S. Geological Survey’s (USGS), Southwest Biological Science Center (SBSC) acquired airborne multispectral high resolution data for the Colorado River in Grand Canyon in Arizona, USA. The imagery data consist of four bands (Band 1 – red, Band 2 – green, Band 3 – blue, and Band 4 – near infrared) with a ground resolution of 20 centimeters (cm). These image data are available to the public as 16-bit GeoTIFF files, which can be read and used by most geographic information system (GIS) and image-processing software. The spatial reference of the image data are in the State Plane (SP) map projection using the central Arizona zone (FIPS 0202) and the North American Datum of 1983 (NAD83) National Adjustment of 2011 (NA2011). The airborne data acquisition was conducted under contract by Fugro Earthdata Inc (Fugro) using two fixed wing aircraft from May 29th to June 4th, 2021 at flight altitudes from approximately 2,440 to 3,350 meters above mean sea level. Fugro produced a corridor-wide mosaic using the best possible flight line images with the least amount of smear, the smallest shadow extent, and clearest, most glint-free water possible. The mosaic delivered by Fugro was then further corrected by GCMRC for smear, shadow extent and water clarity as described in the process steps of this metadata and for previous image acquisitions in Durning et al. (2016) and Davis (2012). 47 ground controls points (GCPs) were used to conduct an independent spatial accuracy assessment by GCMRC. The accuracy calculated from the GCPs is reported at 95% confidence as 0.514 m and a Root Mean Square Error (RMSE) of 0.297 m.