The current study focuses on the analysis of SRM 2585 extracts that were distributed as part of ENTACT. It further introduces a separate recovery experiment, using SRM 2585, designed to shed light on factors that affect analyte loss during extraction, cleanup, instrumental analysis, and data processing. Many compounds have been measured and reported in SRM 2585 to date; cross-referencing these compounds against those detected via NTA provides a unique means with which to critically evaluate NTA performance in a real-world context. The recovery experiment described herein further informs factors (e.g., matrix, extraction procedures) that influence compound identification using NTA. Finally, by analyzing the same mixture of compounds at different concentrations and in the presence and absence of dust matrix, the performance of NTA is evaluated here from a quantitative perspective, rather than a typical qualitative perspective.

This dataset is associated with the following publication: Newton, S., J. Sobus, E. Ulrich, R. Singh, A. Chao, J. McCord, S. Laughlin-Toth, and M. Strynar. Examining NTA Performance and Potential Using Fortified and Reference House Dust as Part of EPA's Non-Targeted Analysis Collaborative Trial (ENTACT). Analytical and Bioanalytical Chemistry. Springer, New York, NY, USA, 412: 4221–4233, (2020).