These data are presented to geochemically characterize glass from the informally named Khonkho tephra, an ashfall deposit that crops out at the Khonkho Wankane archaeological site in Jesus de Machaca, Bolivia. The Khonkho tephra appears to have been emplaced by a major explosive eruption from a currently unknown volcanic source. The unit forms a marker bed at an archaeologically important stratigraphic level. These data are to accompany a publication that describes the tephra-fall deposit and its implications and will eventually be used to correlate the unit to samples from other locations where it crops out and to identify its source volcano and eruption. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.