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    • Cellular senescence:ex vivop53-dependent asymmetric cell kinetics

    Metadata Updated: September 30, 2025

    Cellular senescence is a defining property of euploid cells in culture [1,2]. Cultures derived from cells explanted from tissues of a variety of animal species exhibit a finite number of population doublings before undergoing an irreversible arrest of cell replication. Several genes have been implicated as effectors of senescence in culture. These include genetic components of the Rb and p53 growth regulation pathways [3,4,5,6,7,8] and genes encoding components of telomerase [9,10,11]. The p53 and Rb pathways appear to effect senescence proper, being required for the initial cessation of growth by primary cell cultures [3,8,12,13,14]. In contrast, the ability of telomerase to extend culture life span is limited to cells that have first escaped senescence [8,12,13,14].

    Access & Use Information

    Public: This dataset is intended for public access and use. License: No license information was provided. If this work was prepared by an officer or employee of the United States government as part of that person's official duties it is considered a U.S. Government Work.

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    Dates

    Metadata Created Date July 24, 2025
    Metadata Updated Date September 30, 2025

    Metadata Source

    Harvested from Healthdata.gov

    Other Data Resources

    Additional Metadata

    Resource Type Dataset
    Metadata Created Date July 24, 2025
    Metadata Updated Date September 30, 2025
    Publisher National Institutes of Health
    Maintainer
    NIH
    Identifier https://healthdata.gov/api/views/wtbn-ecdj
    Data First Published 2025-07-14
    Data Last Modified 2025-09-29
    Category NIH
    Public Access Level public
    Bureau Code 009:25
    Metadata Context https://project-open-data.cio.gov/v1.1/schema/catalog.jsonld
    Metadata Catalog ID https://healthdata.gov/data.json
    Schema Version https://project-open-data.cio.gov/v1.1/schema
    Catalog Describedby https://project-open-data.cio.gov/v1.1/schema/catalog.json
    Harvest Object Id 50af4a5c-fcc7-4f4b-bc2d-2613ac25d1df
    Harvest Source Id 651e43b2-321c-4e4c-b86a-835cfc342cb0
    Harvest Source Title Healthdata.gov
    Homepage URL https://healthdata.gov/d/wtbn-ecdj
    Program Code 009:033
    Source Datajson Identifier True
    Source Hash 96aaf945e9985bd71fa7d976ab081996d4bd28138ed3dd025f5e43bfe098e5a7
    Source Schema Version 1.1

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