This dataset was produced by the U.S. Geological Survey (USGS) in cooperation with the Wyoming Water Development Office for the purpose of calculating basin characteristics in preparation for the Wyoming StreamStats application. These datasets are raster representations of various environmental, geological, and land use attributes with the Wyoming StreamStats study area and will be served in the Wyoming StreamStats application to describe delineated watersheds. The StreamStats application provides access to spatial analytical tools that are useful for water-resources planning and management, and for engineering and design purposes. The map-based user interface can be used to delineate drainage areas, get basin characteristics and estimates of flow statistics. To aid in parameterization of mechanistic, statistical, and machine learning models of hydrologic systems in the Wyoming StreamStats study area, flow-conditioned parameter grids (FCPGs) have been generated describing upstream basin elevation, slope, level III and IV ecoregion codes, hydrologic regions, land cover classification, waterbodies, first of the month snow water equivalent (Jan-Jun), soil type, average soil permeability, evapotranspiration Spring and Summer, and modeled 30-year normal climatologies of average annual total precipitation, average monthly total precipitation, average annual daily mean temperature, and average monthly daily mean temperature values within the Wyoming StreamStats study area.