This tabular data set represents mean annual water balance variables as described in Wolock and McCabe (2017) for the period 2000-2014, detrended to 2012, compiled for the NHDPlus version 2.1 data suite (NHDPlusV2) for the conterminous United States. The detrended variables (DT_XXX where XXX is the variable) included are: actual evapotranspiration (DT_AET) , potential evapotranspiration (PET), precipitation (DT_PPT), runoff (DT_RUN) , percent of annual precipitation as snow (DT_SNO) , soil moisture storage (DT_STO), and temperature (DT_TAV). Linkage of these data with NHDPlusV2 is achieved through the common unique identifier COMID. The values are estimated both for: 1) individual reach catchments and 2) reach catchments accumulated upstream through the river network. The reach catchment information characterizes data at the local scale, whereas the catchments accumulated through the river network characterize cumulative upstream conditions. The network-accumulated values are derived using two methods: 1) divergence routing and 2) total upstream routing. Both approaches use a modified routing database (Schwarz and Wieczorek, 2018) to navigate the NHDPlusV2 reach network and to aggregate (accumulate) the metrics derived from the reach catchment scale.