This data set represents annual freshwater withdrawals averaged over the years 1995-2000 compiled for two spatial components of the NHDPlus version 2.1 data suite (NHDPlusv2) for the conterminous United States; 1) individual reach catchments and 2) reach catchments accumulated upstream through the river network. This dataset can be linked to the NHDPlus version 2.1 data suite by the unique identifier COMID. The source data for county-level estimates of freshwater withdrawals from 1995-2000 was produced by the United States Geological Survey (James Falcone, USGS, written communication, 2015). Units are megaliters per year per square kilometer. Reach catchment information characterizes data at the local scale. Reach catchments accumulated upstream through the river network characterizes cumulative upstream conditions. Network-accumulated values are computed using two methods, 1) divergence-routed and 2) total cumulative drainage area. Both approaches use a modified routing database to navigate the NHDPlus version 2.1 reach network to aggregate (accumulate) the metrics derived from the reach catchment scale. (Schwarz and Wieczorek, 2018).