This tabular data set represents population density, persons per square kilometer from 2010 Census block level data, processed by James Falcone (USGS, 2016), compiled for two spatial components of the NHDPlus version 2 data suite (NHDPlusv2) for the conterminous United States; 1) individual reach catchments and 2) reach catchments accumulated upstream through the river network. This dataset can be linked to the NHDPlus version 2 data suite by the unique identifier COMID. The source data for population density was produced by the U.S. Geological Survey (Falcone, 2016). Units are persons per square kilometer. Reach catchment information characterizes data at the local scale. Reach catchments accumulated upstream through the river network characterizes cumulative upstream conditions. Network-accumulated values are computed using two methods, 1) divergence-routed and 2) total cumulative drainage area. Both approaches use a modified routing database to navigate the NHDPlus reach network to aggregate (accumulate) the metrics derived from the reach catchment scale. (Schwarz and Wieczorek, 2018).