5 datasets found
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Federal
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists
U.S. Department of Health & Human Services —
Background The Hedgehog (Hh) signaling pathway is vital to animal development as it mediates the differentiation of multiple cell types during embryogenesis. In... -
Federal
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2
U.S. Department of Health & Human Services —
Background Hedgehog signaling proteins play important roles in development by controlling growth and patterning in various animals including Drosophila and mammals.... -
Federal
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway
U.S. Department of Health & Human Services —
The discovery of small molecules that act as agonists and antagonists of the Hedgehog-Gli signaling pathway, which plays important roles in the embryo and adult,... -
Federal
Roughing up Smoothened: chemical modulators of Hedgehog signaling
U.S. Department of Health & Human Services —
Small-molecule antagonists of Hedgehog-pathway signaling, such as cyclopamine, have been known for some time. Now, small-molecule agonists of the Hedgehog pathway... -
Federal
Agonizing Hedgehog
U.S. Department of Health & Human Services —
It is a rare treat when a drug discovery program teaches us something about the biology of the process that it attempts to modulate. The paper by Maria Frank-...
5 datasets found