2,009 datasets found
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Federal
Development of dengue virus replicons expressing HIV-1 gp120 and other heterologous genes: a potential future tool for dual vaccination against dengue virus and HIV
U.S. Department of Health & Human Services —
Background Toward the goals of providing an additional vector to add to the armamentarium available to HIV vaccinologists and of creating a bivalent vaccine effective... -
Federal
Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs)
U.S. Department of Health & Human Services —
Background: Standard archival sequence databases have not been designed as tools for genome annotation and are far from being optimal for this purpose. We used the... -
Federal
Central effects of clozapine in regulating micturition in anesthetized rats
U.S. Department of Health & Human Services —
Background We previously showed that systemic administration of the atypical neuroleptic clozapine in the rat altered a number of urodynamic variables and inhibited... -
Federal
Brain dystrophin-glycoprotein complex: Persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy
U.S. Department of Health & Human Services —
Background Aside from muscle, brain is also a major expression site for dystrophin, the protein whose abnormal expression is responsible for Duchenne muscular... -
Federal
Approaches to enhancing the retroviral transduction of human synoviocytes
U.S. Department of Health & Human Services —
This report concerns a clinical trial for rheumatoid arthritis (RA), approved by the US National Institutes of Health and the Food and Drug Administration. An... -
Federal
Voluntary self-poisoning as a cause of admission to a tertiary hospital internal medicine clinic in Piraeus, Greece within a year
U.S. Department of Health & Human Services —
Background Out of 1705 patients hospitalised for various reasons in the 3rd Internal Medicine Department of the Regional General Hospital of Nikaea, in Piraeus,... -
Federal
Treatment of established postoperative nausea and vomiting: a quantitative systematic review
U.S. Department of Health & Human Services —
Background The relative efficacy of antiemetics for the treatment of postoperative nausea and vomiting (PONV) is poorly understood. Methods Systematic search... -
Federal
Regular use of aspirin and pancreatic cancer risk
U.S. Department of Health & Human Services —
Background Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and... -
Federal
Clinical significance of cardiovascular dysmetabolic syndrome
U.S. Department of Health & Human Services —
Although diabetes mellitus is predominantly a metabolic disorder, recent data suggest that it is as much a vascular disorder. Cardiovascular complications are the... -
Federal
Aggregation and retention of human urokinase type plasminogen activator in the yeast endoplasmic reticulum
U.S. Department of Health & Human Services —
Background Secretion of recombinant proteins in yeast can be affected by their improper folding in the endoplasmic reticulum and subsequent elimination of the... -
Federal
PKQuest: a general physiologically based pharmacokinetic model. Introduction and application to propranolol
U.S. Department of Health & Human Services —
Background A "physiologically based pharmacokinetic" (PBPK) approach uses a realistic model of the animal to describe the pharmacokinetics. Previous PBPKs have been... -
Federal
Endovascular treatment of huge saccular abdominal aortic aneurysm in a young Behcet patient: mid-term result
U.S. Department of Health & Human Services —
Background Abdominal aortic aneurysm formation is among the arterial complications of Behcet's disease. Weakness and fragility of aortic walls leads to the... -
Federal
Mouse skin passage of a
U.S. Department of Health & Human Services —
Background Streptolysin S (SLS), the oxygen-stable hemolysin of Streptococcus pyogenes, has recently been shown to be encoded by the sagA/pel gene. Mutants lacking... -
Federal
Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer – a phase II study
U.S. Department of Health & Human Services —
Background 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological... -
Federal
Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction
U.S. Department of Health & Human Services —
In the present study, we searched for mutant PTEN transcripts in aggressive rheumatoid arthritis synovial fibroblasts (RA-SF) and studied the expression of PTEN in... -
Federal
Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis
U.S. Department of Health & Human Services —
Background NF1 refers to type 1 neurofibromatosis syndrome, which has been linked with mutations of the large NF1 gene. NF1 tumor suppressor protein, neurofibromin,... -
Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients... -
Federal
An efficient method to successively introduce transgenes into a given genomic locus in the mouse
U.S. Department of Health & Human Services —
Background Expression of transgenes in mice requires transcriptional regulatory elements that direct expression in a chosen cell type. Unfortunately, the availability... -
Federal
Comparison of various characteristics of women who do and do not attend for breast cancer screening
U.S. Department of Health & Human Services —
Background Information regarding the characteristics and health of women who do and do not attend for breast cancer screening is limited and representative data are... -
Federal
Design of a trial evaluating myocardial cell protection with cariporide, an inhibitor of the transmembrane sodium-hydrogen exchanger: the Guard During Ischemia Against Necrosis (GUARDIAN) trial
U.S. Department of Health & Human Services —
Inhibition of the sodium-hydrogen exchanger (NHE) is a powerful experimental tool to inhibit sodium and calcium accumulation within the ischemic myocyte and halt...
2,009 datasets found