2,009 datasets found
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Federal
Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]
U.S. Department of Health & Human Services —
Introduction Treatment of sepsis is aimed at increasing both the duration and quality of survival. A long-term focus on quality of life (QoL) in clinical trial... -
Federal
Prenatal diagnosis of Neu-Laxova syndrome: a case report
U.S. Department of Health & Human Services —
Background Neu-Laxova syndrome is a rare congenital abnormality involving multiple systems. We report a case of Neu-Laxova syndrome (NLS) diagnosed prenatally by... -
Federal
TheG-308Avariant of the Tumor Necrosis Factor-α (TNF-α) gene is not associated with obesity, insulin resistance and body fat distribution
U.S. Department of Health & Human Services —
Tumor Necrosis Factor-α (TNF-α) has been implicated in the pathogenesis of insulin resistance and obesity. The increased expression of TNF-α in adipose tissue has... -
Federal
Selection in the evolution of gene duplications
U.S. Department of Health & Human Services —
Background Gene duplications have a major role in the evolution of new biological functions. Theoretical studies often assume that a duplication per se is selectively... -
Federal
Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?
U.S. Department of Health & Human Services —
Background Mefloquine is a clinically important antimalaria drug, which is often not well tolerated. We critically reviewed 516 published case reports of mefloquine... -
Federal
Full-length messenger RNA sequences greatly improve genome annotation
U.S. Department of Health & Human Services —
Background Annotation of eukaryotic genomes is a complex endeavor that requires the integration of evidence from multiple, often contradictory, sources. With the... -
Federal
Fibroblasts and monocyte macrophages contract and degrade three-dimensional collagen gels in extended co-culture
U.S. Department of Health & Human Services —
Background Inflammatory cells are believed to play a prominent role during tissue repair and remodeling. Since repair processes develop and mature over extended time... -
Federal
Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs
U.S. Department of Health & Human Services —
Background The search for an optimal experimental model in pharmacology is recently focused on (mini)pigs as they seem not only to be an alternative source of cells... -
Federal
A functional update of the
U.S. Department of Health & Human Services —
Background Since the genome of Escherichia coli K-12 was initially annotated in 1997, additional functional information based on biological characterization and... -
Federal
Angiotensin receptor blockers in heart failure after the ELITE II trial
U.S. Department of Health & Human Services —
Specific blockers of the angiotensin type1 receptor, angiotensin receptor blockers (ARBs), have been introduced as an alternative to angiotensin-converting enzyme... -
Federal
Comparative analysis of somitogenesis related genes of the
U.S. Department of Health & Human Services —
Background Members of a class of bHLH transcription factors, namely the hairy (h), Enhancer of split (E(spl)) and hairy-related with YRPW motif (hey) (h/E(spl)/hey)... -
Federal
T-cell-mediated control of autoimmunity
U.S. Department of Health & Human Services —
Inflammatory responses provoked by pathogens are antigen-specific in their induction but are nonspecific in their effects. Consequently, they are potentially damaging... -
Federal
Cytochrome P450 2E1 polymorphism and nasopharyngeal carcinoma development in Thailand: a correlative study
U.S. Department of Health & Human Services —
Background Nasopharyngeal carcinoma (NPC) is a rare tumor in most parts of the world but occurs at relatively high frequency among people of Chinese descent. The... -
Federal
Pro/con ethics debate: Should mechanical ventilation be continued to allow for progression to brain death so that organs can be donated?
U.S. Department of Health & Human Services —
Organ transplants continue to redefine medical frontiers. Unfortunately, current demand for organs far surpasses availability, waiting lists are long and many people... -
Federal
Functional evolution of two subtly different (similar) folds
U.S. Department of Health & Human Services —
Background The function of proteins is a direct consequence of their three-dimensional structure. The structural classification of proteins describes the ways of... -
Federal
Rheumatoid synovial CD4
U.S. Department of Health & Human Services —
CD4+ memory T cells (Tm) from rheumatoid arthritis peripheral blood (RAPB) or peripheral blood from normal donors produced IL-2, whereas fewer cells secreted IFN-γ or... -
Federal
The A54T polymorphism at the intestinal fatty acid binding protein 2 is associated with insulin resistance in glucose tolerant Caucasians
U.S. Department of Health & Human Services —
Background An A54T polymorphism at the fatty acid binding protein 2 (FABP2) locus was found to be associated with insulin resistance in non-diabetic Pima Indians. To... -
Federal
Organizing the Carotid Revascularization Endarterectomy versus Stenting Trial (CREST): National Institutes of Health, Health Care Financing Administration, and industry funding
U.S. Department of Health & Human Services —
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) is a prospective, randomized, multicenter clinical trial of carotid endarterectomy (CEA)... -
Federal
Reversal effects of nomegestrol acetate on multidrug resistance in adriamycin-resistant MCF7 breast cancer cell line
U.S. Department of Health & Human Services —
Background Chemotherapy is important in the systematic treatment of breast cancer. To enhance the response of tumours to chemotherapy, attention has been focused on... -
Federal
Survey of stress ulcer prophylaxis
U.S. Department of Health & Human Services —
Background: No surveys of stress ulcer prophylaxis prescribing in the USA have been conducted since 1995. Since that time, the most comprehensive meta-analysis and...
2,009 datasets found