2,009 datasets found
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Federal
5-Fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report
U.S. Department of Health & Human Services —
Background Severe cardiotoxicity is a documented, but very unusual side-effect of intravenous 5-fluorouracil therapy. The mechanism producing cardiotoxicity is poorly... -
Federal
Minimizing charges associated with the determination of brain death
U.S. Department of Health & Human Services —
Background: The purpose of this study was to evaluate the effect of altering the use of the protocol for brain death determination in traumatically injured patients,... -
Federal
The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
U.S. Department of Health & Human Services —
Background: Protein fold recognition using sequence profile searches frequently allows prediction of the structure and biochemical mechanisms of proteins with an... -
Federal
Comparison of the sensitivity of a 24 h-shell vial assay, and conventional tube culture, in the isolation of Herpes simplex virus – 1 from corneal scrapings
U.S. Department of Health & Human Services —
Background Herpes simplex keratitis is a sight threatening ocular infection. A rapid and specific diagnosis is essential for the institution of specific antiviral... -
Federal
Matrix metalloproteinases in lung biology
U.S. Department of Health & Human Services —
Despite much information on their catalytic properties and gene regulation, we actually know very little of what matrix metalloproteinases (MMPs) do in tissues. The... -
Federal
Characterization of subcellular localization and stability of a splice variant of G alpha
U.S. Department of Health & Human Services —
Background Alternative mRNA splicing of αi2, a heterotrimeric G protein α subunit, has been shown to produce an additional protein, termed sαi2. In the sαi2 splice... -
Federal
Debate: Statins should be used in patients with heart failure
U.S. Department of Health & Human Services —
Treatment to prevent progression of heart failure has been targeted to reverse the consequences of heart failure and to a lesser extent the cause – the... -
Federal
Open access to the scientific journal literature
U.S. Department of Health & Human Services —
None of the advantages of traditional scientific journals need be sacrificed in order to provide free online access to scientific journal articles. Objections that... -
Federal
Flow cytometry analysis of the effect of allopurinol and the dinitroaniline compound (Chloralin) on the viability and proliferation of
U.S. Department of Health & Human Services —
Background Leishmaniasis is a major parasitic disease in the tropical regions. However, Leishmania infantum has recently emerged as a very important cause of... -
Federal
Different effects of antisense RelA p65 and NF-κB1 p50 oligonucleotides on the nuclear factor-κB mediated expression of ICAM-1 in human coronary endothelial and smooth muscle cells
U.S. Department of Health & Human Services —
Background Activation of nuclear factor-κB (NF-κB) is one of the key events in early atherosclerosis and restenosis. We hypothesized that tumor necrosis factor-α... -
Federal
Both subtelomeric regions are required and sufficient for specific DNA fragmentation during macronuclear development in
U.S. Department of Health & Human Services —
Background: Programmed DNA-reorganization and DNA-elimination events take place frequently during cellular differentiation. An extreme form of such processes,... -
Federal
Autocrine regulation of asthmatic airway inflammation: role of airway smooth muscle
U.S. Department of Health & Human Services —
Chronic airway inflammation is one of the main features of asthma. Release of mediators from infiltrating inflammatory cells in the airway mucosa has been proposed to... -
Federal
Echocardiography: a fundamental part of the intensive care curriculum
U.S. Department of Health & Human Services —
Echocardiography: a fundamental part of the intensive care curriculum -
Federal
Response ofEscherichia colicontaining mycobacterial carotene genes to UV radiation
U.S. Department of Health & Human Services —
Carotenoid pigments are largely distributed in nature. They are present in all of the photosynthetic organisms as well as in some bacteria, fungi, and yeast [1]. Two... -
Federal
An innovative approach to developing the reflective skills of medical students
U.S. Department of Health & Human Services —
Background Development of the reflective skills of medical students is an acknowledged objective of medical education. Description Description of an educational... -
Federal
Multi-exon deletions of the
U.S. Department of Health & Human Services —
Background Mutations in the fibrillin -1 gene (FBN1) cause Marfan syndrome (MFS), an autosomal dominant multi-system connective tissue disorder. The 200 different... -
Federal
Empirical characterization of the expression ratio noise structure in high-density oligonucleotide arrays
U.S. Department of Health & Human Services —
Background High-density oligonucleotide arrays (HDONAs) are a powerful tool for assessing differential mRNA expression levels. To establish the statistical... -
Federal
Physiologic role of interleukin-1 receptor antagonist
U.S. Department of Health & Human Services —
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different... -
Federal
The effect on endothelial function of vitamin C during methionine induced hyperhomocysteinaemia
U.S. Department of Health & Human Services —
Background Manipulation of total homocysteine concentration with oral methionine is associated with impairment of endothelial-dependent vasodilation. This may be... -
Federal
Percutaneous tracheostomy: comparison of Ciaglia and Griggs techniques
U.S. Department of Health & Human Services —
Background: Although the standard tracheostomy described in 1909 by Jackson has been extensively used in critical patients, a more simple procedure that can be...
2,009 datasets found