2,009 datasets found
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Federal
Defining signal thresholds in DNA microarrays: exemplary application for invasive cancer
U.S. Department of Health & Human Services —
Background Genome-wide or application-targeted microarrays containing a subset of genes of interest have become widely used as a research tool with the prospect of... -
Federal
Gene therapy in rheumatoid arthritis: how to target joint destruction?
U.S. Department of Health & Human Services —
Gene therapy in rheumatoid arthritis: how to target joint destruction? -
Federal
From immunoglobulin gene fingerprinting to motif-specific hybridization: advances in the analysis of B lymphoid clonality in rheumatic diseases
U.S. Department of Health & Human Services —
In rheumatic diseases, autoantibody-producing cells of interest are often hidden in a polyclonal B-lymphocyte population. Immunoglobulin gene fingerprinting is a... -
Federal
Di-, tri- and tetra-5'-
U.S. Department of Health & Human Services —
Background The human FHIT gene is inactivated early in the development of many human cancers and loss of Fhit in mouse predisposes to cancer while reintroduction of... -
Federal
Mini-laparoscopic versus laparoscopic approach to appendectomy
U.S. Department of Health & Human Services —
Background The purpose of this clinical study is to evaluate the feasibility of using 2-mm laparoscopic instruments to perform an appendectomy in patients with... -
Federal
Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health
U.S. Department of Health & Human Services —
Background Acidogenic, acid-tolerant bacteria induce dental caries and require D-alanyl glycerol lipoteichoic acid (D-alanyl LTA) on their cell surface. Because... -
Federal
Prolonged exposure of chromaffin cells to nitric oxide down-regulates the activity of soluble guanylyl cyclase and corresponding mRNA and protein levels
U.S. Department of Health & Human Services —
Background Soluble guanylyl cyclase (sGC) is the main receptor for nitric oxide (NO) when the latter is produced at low concentrations. This enzyme exists mainly as a... -
Federal
Inability of Serotonin to Activate the c-Jun N-terminal Kinase and p38 Kinase Pathways in Rat Aortic Vascular Smooth Muscle Cells
U.S. Department of Health & Human Services —
Background Serotonin (5-HT, 5-hydroxytryptamine) activates the Extracellular Signal-Regulated Kinase (ERK)/ Mitogen-Activated Protein Kinase (MAPK) pathways, in... -
Federal
Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
U.S. Department of Health & Human Services —
The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a... -
Federal
Apical accumulation of MARCKS in neural plate cells during neurulation in the chick embryo
U.S. Department of Health & Human Services —
Background The neural tube is formed by morphogenetic movements largely dependent on cytoskeletal dynamics. Actin and many of its associated proteins have been... -
Federal
A missense mutation (Q279R) in the Fumarylacetoacetate Hydrolase gene, responsible for hereditary tyrosinemia, acts as a splicing mutation
U.S. Department of Health & Human Services —
Background Tyrosinemia type I, the most severe disease of the tyrosine catabolic pathway is caused by a deficiency in fumarylacetoacetate hydrolase (FAH). A patient... -
Federal
Transcriptional territories in the genome
U.S. Department of Health & Human Services —
An analysis of numerous Drosophila microarray experiments reveals that the genome has many large groups of adjacent genes that are expressed similarly but are not... -
Federal
Constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins
U.S. Department of Health & Human Services —
Background Detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. We developed and implemented a simple relative... -
Federal
First Siena International Conference on Animal Models of Chronic Obstructive Pulmonary Disease, Certosa di Pontignano, University of Siena, Italy, September 30-October 2, 2001
U.S. Department of Health & Human Services —
The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease (COPD). COPD is caused by cigarette smoking,... -
Federal
Polyethyleneimine-mediated transfection of cultured postmitotic neurons from rat sympathetic ganglia and adult human retina
U.S. Department of Health & Human Services —
Background Chemical methods of transfection that have proven successful with cell lines often do not work with primary cultures of neurons. Recent data, however,... -
Federal
IFNγ production in peripheral blood of early Lyme disease patients to hLFAα
U.S. Department of Health & Human Services —
Background It has been proposed that outer surface protein A (OspA) of Borrelia burgdorferi sensu stricto contains a T helper 1 (Th1) cell epitope that could play a... -
Federal
Joint disease caused by defective gp130-mediated STAT signaling
U.S. Department of Health & Human Services —
IL-6 is a multifunctional cytokine produced by lymphoid and nonlymphoid cells; it regulates immune responses, acute-phase reactions, and inflammation. IL-6 signaling... -
Federal
Thefrizzledpathway regulates the development of arista laterals.
U.S. Department of Health & Human Services —
Thefrizzledpathway in Drosophila has been studied intensively for its role in the development of planar polarity in wing hairs, thoracic bristles and ommatidia.... -
Federal
Abdominal compartment syndrome
U.S. Department of Health & Human Services —
The abdominal compartment syndrome represents the pathophysiologic consequence of a raised intra-abdominal pressure. Various clinical conditions are associated with... -
Federal
Killing ofMycobacterium aviumsubspeciesparatuberculosiswithin macrophages
U.S. Department of Health & Human Services —
Mycobacterium aviumsubspeciesparatuberculosis(M. paratuberculosis) is a facultative intracellular pathogen that resides within host macrophages during infection of...
2,009 datasets found