2,009 datasets found
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Federal
Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death
U.S. Department of Health & Human Services —
Background Cholesterol oxides, the oxygenated derivatives of cholesterol, have been shown to cause programmed cell death in a variety of cell types. Using N9... -
Federal
Kinetic comparison of tissue non-specific and placental human alkaline phosphatases expressed in baculovirus infected cells: application to screening for Down's syndrome
U.S. Department of Health & Human Services —
Background In humans, there are four alkaline phosphatases, and each form exibits a characteristic pattern of tissue distribution. The availability of an easy method... -
Federal
Decreased insulin binding to mononuclear leucocytes and erythrocytes from dogs after S-Nitroso-N-Acetypenicillamine administration
U.S. Department of Health & Human Services —
Background Nitric oxide (NO) and oxygen free-radicals play an important part in the destruction of beta-cells in auto- immune diabetes although the precise mechanism... -
Federal
Percutaneous tracheostomy
U.S. Department of Health & Human Services —
Percutaneous tracheostomy (PT) has gained an increasing acceptance as an alternative to the conventional surgical tracheostomy (ST). In experienced hands, and with... -
Federal
Fibroblast biology: Signals targeting the synovial fibroblast in arthritis
U.S. Department of Health & Human Services —
Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to... -
Federal
A new device for measurement of fibrin clot lysis: application to the Euglobulin Clot Lysis Time
U.S. Department of Health & Human Services —
Background Determination of clot lysis times on whole blood, diluted whole blood, plasma or plasma fraction has been used for many years to assess the overall... -
Federal
Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: decreased expression of heat shock proteins
U.S. Department of Health & Human Services —
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial... -
Federal
Construction and high cytoplasmic expression of a tumoricidal single-chain antibody against hepatocellular carcinoma
U.S. Department of Health & Human Services —
Background Hep27 monoclonal (Hep27 Mab) is an antibody against hepatocellular carcinoma. Hep27 Mab itself can inhibit the growth of a hepatocellular carcinoma cell... -
Federal
Reinforcement of genetic coherence in a two-locus model
U.S. Department of Health & Human Services —
Background In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing... -
Federal
Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention
U.S. Department of Health & Human Services —
Cytokines and direct cell contact in synovitis: relevance to therapeutic intervention -
Federal
Phospholipase Cδ regulates germination of
U.S. Department of Health & Human Services —
Background Many eukaryotes, including plants and fungi make spores that resist severe environmental stress. The micro-organism Dictyostelium contains a single... -
Federal
Diuretics: again the first step in the treatment of most patients with hypertension
U.S. Department of Health & Human Services —
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to... -
Federal
Some provocative thoughts on damage and repair of DNA
U.S. Department of Health & Human Services —
Some provocative thoughts on damage and repair of DNA -
Federal
Gene targeting in mosquito cells: a demonstration of 'knockout' technology in extrachromosomal gene arrays
U.S. Department of Health & Human Services —
Background Gene targeting would offer a number of advantages over current transposon-based strategies for insect transformation. These include freedom from both... -
Federal
Reporting of measures of accuracy in systematic reviews of diagnostic literature
U.S. Department of Health & Human Services —
Background There are a variety of ways in which accuracy of clinical tests can be summarised in systematic reviews. Variation in reporting of summary measures has... -
Federal
Expense and benefit of neoadjuvant treatment in squamous cell carcinoma of the esophagus
U.S. Department of Health & Human Services —
Background The effectiveness of neoadjuvant treatment (NT) prior to resection of squamous cell carcinoma of the esophagus (SCCE) in terms of prolonged survival has... -
Federal
Latent transforming growth factor β-binding protein-3 and fibulin-1C interact with the extracellular domain of the heparin-binding EGF-like growth factor precursor
U.S. Department of Health & Human Services —
Background The membrane-bound cell-surface precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to many... -
Federal
CMV infection of liver transplant recipients: comparison of antigenemia and molecular biology assays
U.S. Department of Health & Human Services —
Background CMV is a major clinical problem in transplant recipients. Thus, it is important to use sensitive and specific diagnostic techniques to rapidly and... -
Federal
Combinatorial diversity of fission yeast SCF ubiquitin ligases by homo- and heterooligomeric assemblies of the F-box proteins Pop1p and Pop2p
U.S. Department of Health & Human Services —
Background SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind... -
Federal
An algorithm for mapping positively selected members of quasispecies-type viruses
U.S. Department of Health & Human Services —
Background Many RNA viruses do not have a single, representative genome but instead form a set of related variants that has been called a quasispecies. The sequence...
2,009 datasets found