2,009 datasets found
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Federal
The concentration of three anti-seizure medications in hair: the effects of hair color, controlling for dose and age
U.S. Department of Health & Human Services —
Background This paper assess the relationship between the quantity of three anti-seizure medications in hair and the color of the analyzed hair, while controlling for... -
Federal
Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice
U.S. Department of Health & Human Services —
Anti-tumor-necrosis-factor-α (TNF-α) monoclonal antibody was used to treat Tg197 transgenic mice, which constitutively produce human TNF-α (hTNF-α) and develop a... -
Federal
Notch signalling is linked to epidermal cell differentiation level in basal cell carcinoma, psoriasis and wound healing
U.S. Department of Health & Human Services —
Background Epidermal homeostasis involves the monitoring of continuous proliferative and differentiative processes as keratinocytes migrate from the basal layer to... -
Federal
Analysis of a human brain transcriptome map
U.S. Department of Health & Human Services —
Background Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our... -
Federal
Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation
U.S. Department of Health & Human Services —
Background Transgenic mice have been used extensively to analyze gene function. Unfortunately, traditional transgenic procedures have only limited use in analyzing... -
Federal
Tissue factor as a proinflammatory agent
U.S. Department of Health & Human Services —
Tissue factor (TF) is a transmembrane glycoprotein and the main triggering element of blood coagulation. TF expression on monocytes and endothelial cells is induced... -
Federal
Evaluation of amplified rDNA restriction analysis (ARDRA) for the identification of cultured mycobacteria in a diagnostic laboratory
U.S. Department of Health & Human Services —
Background The development of DNA amplification for the direct detection of M. tuberculosis from clinical samples has been a major goal of clinical microbiology... -
Federal
Alteration in expression of the rat mitochondrial ATPase 6 gene during
U.S. Department of Health & Human Services —
Background Pneumocystis carinii causes pneumonia in immunocompromised patients with a high morbidity and mortality rate, but the interaction between this organism and... -
Federal
Inflammatory microcrystals induce murine macrophage survival and DNA synthesis
U.S. Department of Health & Human Services —
The interaction of particulates with resident macrophages is a consistent feature in certain forms of crystal-induced inflammation, for example, in synovial tissues,... -
Federal
Clinical utility of a nested nucleic acid amplification format in comparison to viral culture for the diagnosis of mucosal herpes simplex infection in a genitourinary medicine setting
U.S. Department of Health & Human Services —
Background Nested nucleic acid amplification tests are often thought too sensitive or prone to generatingfalse positive results for routine use. The current study... -
Federal
Two pathways act in an additive rather than obligatorily synergistic fashion to induce systemic acquired resistance and
U.S. Department of Health & Human Services —
Background Local infection with necrotizing pathogens induces whole plant immunity to secondary challenge. Pathogenesis-related genes are induced in parallel with... -
Federal
Is there a role for glucocorticoid receptor beta in asthma?
U.S. Department of Health & Human Services —
Glucocorticoids (GCs) are routinely used as anti-inflammatory drugs in the treatment of asthma. They act through binding to glucocorticoid receptor α (GRα), which... -
Federal
Phenotypic characteristics of human monocytes undergoing transendothelial migration
U.S. Department of Health & Human Services —
In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found that monocyte migration led... -
Federal
Toll-like receptors: the key to the stable door?
U.S. Department of Health & Human Services —
Severe sepsis continues to lead to critical illness. Few therapeutic options exist other than antibiotic therapy and general supportive care. Large numbers of... -
Federal
The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
U.S. Department of Health & Human Services —
The lung responds to a variety of insults in a remarkably consistent fashion but with inconsistent outcomes that vary from complete resolution and return to normal to... -
Federal
Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin
U.S. Department of Health & Human Services —
Background Elevated plasma counts of endothelial microparticles (MP) have been demonstrated in various diseases with a vascular injury component. We used flow... -
Federal
Role of arginine and its methylated derivatives in cancer biology and treatment
U.S. Department of Health & Human Services —
Both L-arginine supplementation and deprivation influence cell proliferation. The effect of high doses on tumours is determined by the optical configuration:... -
Federal
Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
U.S. Department of Health & Human Services —
Background We have previously reported that glycerol acts as a chemical chaperone to restore the expression of WAF1 in some human cancer cell lines bearing mutant... -
Federal
Statistics review 2: Samples and populations
U.S. Department of Health & Human Services —
The previous review in this series introduced the notion of data description and outlined some of the more common summary measures used to describe a dataset.... -
Federal
Rhinocerebral mucormycosis treated with 32 gram liposomal amphotericin B and incomplete surgery: a case report
U.S. Department of Health & Human Services —
Background Mucormycosis (or zygomycosis) is the term for infection caused by fungi of the order Mucorales. Mucoraceae may produce severe disease in susceptible...
2,009 datasets found