2,009 datasets found
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Federal
Aged garlic extract therapy for sickle cell anemia patients
U.S. Department of Health & Human Services —
Background Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a... -
Federal
Clues to the etiology of autoimmune diseases through analysis of immunoglobulin genes
U.S. Department of Health & Human Services —
The role of autoantibodies in the etiology of autoimmune diseases remains unclear. However, an examination of the sequences of these autoantibodies can be... -
Federal
Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis
U.S. Department of Health & Human Services —
Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than... -
Federal
The impact of incident vertebral and non-vertebral fractures on health related quality of life in postmenopausal women
U.S. Department of Health & Human Services —
Background Little empirical research has examined the multiple consequences of osteoporosis on quality of life. Methods Health related quality of life (HRQL) was... -
Federal
Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies
U.S. Department of Health & Human Services —
Background We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time... -
Federal
Debate: Unstable angina - When should we intervene?
U.S. Department of Health & Human Services —
The prognosis of patients who present with non-ST segment elevation acute coronary syndromes (ACS) is guarded. These patients can be risk-stratified on the basis of... -
Federal
Effects of intravenous furosemide on mucociliary transport and rheological properties of patients under mechanical ventilation
U.S. Department of Health & Human Services —
The use of intravenous (IV) furosemide is common practice in patients under mechanical ventilation (MV), but its effects on respiratory mucus are largely unknown.... -
Federal
Growth factors in lung development and disease: friends or foe?
U.S. Department of Health & Human Services —
Growth factors mediate tissue interactions and regulate a variety of cellular functions that are critical for normal lung development and homeostasis. Besides their... -
Federal
Immunity status against poliomyelitis in Germany: Determination of cut-off values in International Units
U.S. Department of Health & Human Services —
Background To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for... -
Federal
Asymmetric directional mutation pressures in bacteria
U.S. Department of Health & Human Services —
When there are no strand-specific biases in mutation and selection rates between the two strands of DNA, the average nucleotide composition is theoretically expected... -
Federal
Fibroblast biology: Effector signals released by the synovial fibroblast in arthritis
U.S. Department of Health & Human Services —
There is mounting evidence indicating that the synovial fibroblast is a direct effector of tissue injury and matrix remodeling in inflammatory synovitis. Through the... -
Federal
Multi site polyadenylation and transcriptional response to stress of a vacuolar type H
U.S. Department of Health & Human Services —
Background Vacuolar type H+-ATPases play a critical role in the maintenance of vacuolar homeostasis in plant cells. V-ATPases are also involved in plants' defense... -
Federal
Long-term reductions in tinnitus severity
U.S. Department of Health & Human Services —
Background This study was undertaken to assess long-term changes in tinnitus severity exhibited by patients who completed a comprehensive tinnitus management program;... -
Federal
eHealth Applications in Health Care Management
U.S. Department of Health & Human Services —
eHealth Applications in Health Care Management -
Federal
Laryngeal dysfunction in Amyotrophic Lateral Sclerosis: a review and case report
U.S. Department of Health & Human Services —
Background Laryngeal dysfunction can be a salient feature in the clinical symptomatology of speakers diagnosed with Amyotrophic Lateral Sclerosis (ALS). In addition... -
Federal
The role of X-chromosome inactivation in female predisposition to autoimmunity
U.S. Department of Health & Human Services —
We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed... -
Federal
Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination
U.S. Department of Health & Human Services —
Background In most endemic parts of the world, onchocerciasis (river blindness) control relies, or will soon rely, exclusively on mass treatment with the... -
Federal
Adaptations to iron deficiency: cardiac functional responsiveness to norepinephrine, arterial remodeling, and the effect of beta-blockade on cardiac hypertrophy
U.S. Department of Health & Human Services —
Background Iron deficiency (ID) results in ventricular hypertrophy, believed to involve sympathetic stimulation. We hypothesized that with ID 1) intravenous... -
Federal
Size does matter: overcoming the adeno-associated virus packaging limit
U.S. Department of Health & Human Services —
Recombinant adeno-associated virus (rAAV) vectors mediate long-term gene transfer without any known toxicity. The primary limitation of rAAV has been the small size... -
Federal
The life cycle of chondrocytes in the developing skeleton
U.S. Department of Health & Human Services —
Cartilage serves multiple functions in the developing embryo and in postnatal life. Genetic mutations affecting cartilage development are relatively common and lead...
2,009 datasets found