2,009 datasets found
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Federal
Support Vector Machines for predicting protein structural class
U.S. Department of Health & Human Services —
Background We apply a new machine learning method, the so-called Support Vector Machine method, to predict the protein structural class. Support Vector Machine method... -
Federal
Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop
U.S. Department of Health & Human Services —
Background The mechanisms by which alpha-2 adrenergic receptors are down-regulated following chronic exposure to agonist are not well understood. Interestingly, the... -
Federal
Omapatrilat normalizes renal function curve in spontaneously hypertensive rats
U.S. Department of Health & Human Services —
Background The present study was designed to analyze the chronic renal response to omapatrilat, a new vasopeptidase inhibitor, in spontaneously hypertensive rats... -
Federal
Conservation of the COP9/signalosome in budding yeast
U.S. Department of Health & Human Services —
Background The COP9/signalosome (CSN), a multiprotein complex consisting of eight subunits, is implicated in a wide variety of regulatory processes including cell... -
Federal
Scanning laser Doppler is a useful technique to assess foot cutaneous perfusion during femoral artery cannulation
U.S. Department of Health & Human Services —
Background: Measurement of cardiac output and extravascular lung water in critically ill patients using femoral artery double-indicator dilution involves femoral... -
Federal
Schönlein-Henoch purpura during pregnancy with successful outcome for mother and newborn
U.S. Department of Health & Human Services —
Background Schönlein-Henoch purpura is a systemic vasculitis that affects vessels of a small caliber and rarely reported in the literature. Case presentation We... -
Federal
Proinflammatory activity of TWEAK on human dermal fibroblasts and synoviocytes: blocking and enhancing effects of anti-TWEAK monoclonal antibodies
U.S. Department of Health & Human Services —
Human tumour necrosis factor (TNF)-like weak inducer of apoptosis (hTWEAK) and two anti-hTWEAK mAbs were tested for their ability to elicit or block inflammatory... -
Federal
Expression profiling of
U.S. Department of Health & Human Services —
A combination of linear RNA amplification and DNA microarray hybridization has allowed the determination of expression profiles of individual imaginal discs and... -
Federal
High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition
U.S. Department of Health & Human Services —
Background In perfused hearts, high calcium-induced inotropy results in less developed pressure relative to myocardial oxygen consumption compared to the β-adrenergic... -
Federal
Research Article: BMC Biotechnology
U.S. Department of Health & Human Services —
Background The suitability of the strain Rhodococcus erythropolis ATCC 25544 grown in a two-liter fermentor as a source of cholesterol oxidase has been investigated.... -
Federal
Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis
U.S. Department of Health & Human Services —
Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with... -
Federal
Mapping of the Mouse Actin Capping Protein Beta Subunit Gene
U.S. Department of Health & Human Services —
Background Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls... -
Federal
Major genomic mitochondrial lineages delineate early human expansions
U.S. Department of Health & Human Services —
Background The phylogeographic distribution of human mitochondrial DNA variations allows a genetic approach to the study of modern Homo sapiens dispersals throughout... -
Federal
A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale
U.S. Department of Health & Human Services —
Background The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-... -
Federal
Lowering of lipid composition in aorta of guinea pigs by
U.S. Department of Health & Human Services —
Background A short-term study was carried out using guinea pigs to determine the effects of Curcuma domestica on lipid composition in the serum and aorta. Methods... -
Federal
Reporting of adverse drug reactions in randomised controlled trials – a systematic survey
U.S. Department of Health & Human Services —
Background Decisions on treatment are guided, not only by the potential for benefit, but also by the nature and severity of adverse drug reactions. However, some... -
Federal
Molecular action of methotrexate in inflammatory diseases
U.S. Department of Health & Human Services —
Despite the recent introduction of biological response modifiers and potent new small-molecule antirheumatic drugs, the efficacy of methotrexate is nearly unsurpassed... -
Federal
Prediction models in the design of neural network based ECG classifiers: A neural network and genetic programming approach
U.S. Department of Health & Human Services —
Background Classification of the electrocardiogram using Neural Networks has become a widely used method in recent years. The efficiency of these classifiers depends... -
Federal
Joint-specific and systemic autoreactivity in the development of inflammatory arthritis
U.S. Department of Health & Human Services —
Joint-specific and systemic autoreactivity in the development of inflammatory arthritis -
Federal
Two novel frame shift, recurrent and
U.S. Department of Health & Human Services —
We have identified four different mutations causing leukocyte adhesion deficiency (LAD) in the ITGB2 gene of patients from a highly inbred population. Two were novel...
2,009 datasets found