2,009 datasets found
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Federal
Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo
U.S. Department of Health & Human Services —
Background Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive... -
Federal
Equipment review: Mechanical effects of heat-moisture exchangers in ventilated patients
U.S. Department of Health & Human Services —
Although they represent a valuable alternative to heated humidifiers, artificial noses have unfavourable mechanical effects. Most important of these is the increase... -
Federal
Genetic counselling for hypertrophic cardiomyopathy: are we ready for it?
U.S. Department of Health & Human Services —
Hypertrophic cardiomyopathy (HCM) is a dominant genetic disorder of the myocardium associated with dysfunctional contractile proteins. The major risk of HCM is sudden... -
Federal
A clustering method for repeat analysis in DNA sequences
U.S. Department of Health & Human Services —
Background A computational system for analysis of the repetitive structure of genomic sequences is described. The method uses suffix trees to organize and search the... -
Federal
Reliability, validity and psychometric properties of the Greek translation of the zung depression rating scale
U.S. Department of Health & Human Services —
Introduction The current study aimed to assess the reliability, validity and psychometric properties of the Greek translation of the Zung Depression Rating Scale... -
Federal
Advances in Targeted Therapies III, Nassau, Bahamas, 27 April-1 May 2001
U.S. Department of Health & Human Services —
This conference was the third in a series focusing on developments in the therapy of rheumatoid arthritis (RA) and other rheumatic conditions with biologicals; in... -
Federal
Research Article: BMC Genetics
U.S. Department of Health & Human Services —
Background Glucose repression of transcription in the yeast, Saccharomyces cerevisiae, has been shown to be controlled by several factors, including two repressors... -
Federal
Cellular responses to
U.S. Department of Health & Human Services —
Background Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would... -
Federal
Research Article: Genome Biology
U.S. Department of Health & Human Services —
Background Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous... -
Federal
Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kB.
U.S. Department of Health & Human Services —
Background Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of... -
Federal
Chromosomal mapping, gene structure and characterization of the human and murine
U.S. Department of Health & Human Services —
Background Rab GTPases are regulators of intracellular membrane traffic. The Rab27 subfamily consists of Rab27a and Rab27b. Rab27a has been recently implicated in... -
Federal
The human Y chromosome: the biological role of a “functional wasteland”
U.S. Department of Health & Human Services —
“Functional wasteland,” “Nonrecombining desert,” and “Gene-poor chromosome” are only some examples of the different definitions given to the Y chromosome in the last... -
Federal
HumanCCSgene: genomic organization and exclusion as a candidate for amyotrophic lateral sclerosis (ALS)
U.S. Department of Health & Human Services —
Amyotrophic lateral sclerosis (ALS) is a progressive lethal disorder of large motor neurons of the spinal cord and brain. In approximately 20% of the familial and 2%... -
Federal
Specificity of T cells in synovial fluid: high frequencies of CD8
U.S. Department of Health & Human Services —
CD8+ T cells dominate the lymphocyte population in synovial fluid in chronic inflammatory arthritis. It is known that these CD8+ T cells are often clonally or... -
Federal
ELITE II and Val-HeFT are different trials: together what do they tell us?
U.S. Department of Health & Human Services —
The Losartan Heart Failure Survival Study (ELITE II) and the Valsartan Heart Failure Trial (Val-HeFT) both evaluated the efficacy and tolerability of a selective... -
Federal
The methionine salvage pathway in
U.S. Department of Health & Human Services —
Background Polyamine synthesis produces methylthioadenosine, which has to be disposed of. The cell recycles it into methionine through methylthioribose (MTR). Very... -
Federal
Debate: PCI or CABG for multivessel disease? Viewpoint: No clear winner in an unfair fight
U.S. Department of Health & Human Services —
The Arterial Revascularization Therapy Study (ARTS) and the Stent or Surgery (SoS) trial each randomized patients with multivessel disease to either stenting or... -
Federal
Research Article: BMC Pharmacology
U.S. Department of Health & Human Services —
Background Evidence suggests that both the migration and activation of neutrophils into the airway is of importance in pathological conditions such as pulmonary... -
Federal
Continuing HIV therapy in the ICU
U.S. Department of Health & Human Services —
The risks and benefits of stopping antiretroviral therapy in patients admitted to the ICU are largely unmeasured. In many cases therapy has to be stopped, as... -
Federal
Role of endothelin-1 in lung disease
U.S. Department of Health & Human Services —
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of...
2,009 datasets found