2,009 datasets found
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Federal
Retrovirus-delivered siRNA
U.S. Department of Health & Human Services —
The ability of transfected synthetic small interfering (si) RNAs to suppress the expression of specific transcripts has proved a useful technique to probe gene... -
Federal
Differentiation of monocytes into multinucleated giant bone-resorbing cells: two-step differentiation induced by nurse-like cells and cytokines
U.S. Department of Health & Human Services —
Bone resorption in the joints is the characteristic finding in patients with rheumatoid arthritis (RA). Osteoclast-like cells are present in the synovial tissues and... -
Federal
Cell density related gene expression: SV40 large T antigen levels in immortalized astrocyte lines
U.S. Department of Health & Human Services —
Background Gene expression is affected by population density. Cell density is a potent negative regulator of cell cycle time during exponential growth. Here, we asked... -
Federal
Analysis of the myosins encoded in the recently completed
U.S. Department of Health & Human Services —
Background Three types of molecular motors play an important role in the organization, dynamics and transport processes associated with the cytoskeleton. The myosin... -
Federal
Worldwide trends in mortality from biliary tract malignancies
U.S. Department of Health & Human Services —
Background Intrahepatic cholangiocarcinomas are malignant tumors arising from the intrahepatic biliary tract. The pathogenesis of these tumors remains unknown.... -
Federal
Blood borne transit of CJD from brain to gut at early stages of infection
U.S. Department of Health & Human Services —
Background In Creutzfeldt-Jakob disease (CJD) and other related transmissible spongiform encephalopathies it is critical to understand the various pathways by which... -
Federal
Induced cytoskeletal changes in bovine pulmonary artery endothelial cells by resveratrol and the accompanying modified responses to arterial shear stress
U.S. Department of Health & Human Services —
Background Atherosclerosis and coronary heart disease (CHD) are significant contributors to morbidity and mortality in developed countries. A noted exception is the... -
Federal
Bacterial cholangitis causing secondary sclerosing cholangitis: A case report
U.S. Department of Health & Human Services —
Background Although bacterial cholangitis is frequently mentioned as a cause of secondary sclerosing cholangitis, it appears to be extremely rare, with only one... -
Federal
Mutational analyses of the signals involved in the subcellular location of DSCR1
U.S. Department of Health & Human Services —
Background Down syndrome is the most frequent genetic disorder in humans. Rare cases involving partial trisomy of chromosome 21 allowed a small chromosomal region... -
Federal
Research Article: Current Controlled Trials in Cardiovascular Medicine
U.S. Department of Health & Human Services —
Some problems with the quality of controlled clinical trials can be addressed by following these procedures: registering all trials at inception; using systematic... -
Federal
Negative regulation of mitochondrial VDAC channels by C-Raf kinase
U.S. Department of Health & Human Services —
Background Growth of cancer cells results from the disturbance of positive and negative growth control mechanisms and the prolonged survival of these genetically... -
Federal
Lack of autoantibody production associated with cytomegalovirus infection
U.S. Department of Health & Human Services —
To confirm an association between cytomegalovirus (CMV) infection and the presence of antibodies to Smith (Sm), to ribonucleoprotein (RNP), and to a component of the... -
Federal
Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G
U.S. Department of Health & Human Services —
Background Tissues that depend on aerobic energy metabolism suffer most in diseases caused by mutations in mitochondrial DNA (mtDNA). Cardiac abnormalities have been... -
Federal
Debate: The potential role of estrogen in the prevention of heart disease in women after menopause
U.S. Department of Health & Human Services —
The observational studies of hormone users are compromised by systematic biases that lead to an overestimation of benefit and an underestimation of risk. Studies of... -
Federal
Ablation of atrial fibrillation: a procedure come of age?
U.S. Department of Health & Human Services —
Various approaches for catheter ablation of focal initiators of atrial fibrillation or the substrate for maintaining atrial fibrillation have evolved over the past 5... -
Federal
Debate: Transfusing to normal haemoglobin levels will not improve outcome
U.S. Department of Health & Human Services —
Recent evidence suggests that critically ill patients are able to tolerate lower levels of haemoglobin than was previously believed. It is our goal to show that... -
Federal
Cloning and characterization of the mouse
U.S. Department of Health & Human Services —
Background Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities.... -
Federal
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review
U.S. Department of Health & Human Services —
This review provides a detailed overview of the current state of knowledge about the ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various... -
Federal
Determinants of blood pH in health and disease
U.S. Department of Health & Human Services —
An advanced understanding of acid–base physiology is as central to the practice of critical care medicine, as are an understanding of cardiac and pulmonary... -
Federal
Understanding childhood asthma in focus groups: perspectives from mothers of different ethnic backgrounds
U.S. Department of Health & Human Services —
Background Diagnosing childhood asthma is dependent upon parental symptom reporting but there are problems in the use of words and terms. The purpose of this study...
2,009 datasets found