2,009 datasets found
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Federal
Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes
U.S. Department of Health & Human Services —
To assess whether the pattern of high rates of genome rearrangement, with a bias towards within-chromosome events is true of nematodes in general, genome sequence was... -
Federal
Serovar distribution of a DNA sequence involved in the antigenic relationship between
U.S. Department of Health & Human Services —
Background Horses infected with Leptospira present several clinical disorders, one of them being recurrent uveitis. A common endpoint of equine recurrent uveitis is... -
Federal
Cell-cell interactions in synovitis: Interactions between T cells and B cells in rheumatoid arthritis
U.S. Department of Health & Human Services —
In rheumatoid arthritis, T cells and B cells participate in the immune responses evolving in the synovial lesions. Interaction between T cells and B cells is probably... -
Federal
Routine prophylactic antibiotic use in the management of snakebite
U.S. Department of Health & Human Services —
Background Routine antibiotic prophylaxis following snakebite is not recommended but evidence suggests that it may be common practice in Zimbabwe. This study set out... -
Federal
Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
U.S. Department of Health & Human Services —
Destruction of cartilage and bone are hallmarks of human rheumatoid arthritis (RA), and controlling these erosive processes is the most challenging objective in the... -
Federal
Morphological, histochemical, and interstitial pressure changes in the tibialis anterior muscle before and after aortofemoral bypass in patients with peripheral arterial occlusive disease
U.S. Department of Health & Human Services —
Background Morphological and electrophysiological studies of ischemic muscles in peripheral arterial disease disclosed evidence of denervation and fibre atrophy. The... -
Federal
Development of Dengue virus type 2 replicons capable of prolonged expression in host cells
U.S. Department of Health & Human Services —
Background As part of a program to develop a Dengue virus vaccine which avoids the deleterious effects of antibody dependent enhancement (ADE) of infection mediated... -
Federal
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
U.S. Department of Health & Human Services —
Background: Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a surge in demand for different types... -
Federal
Inhaled nitric oxide in persistent pulmonary hypertension of the newborn refractory to high-frequency ventilation
U.S. Department of Health & Human Services —
Background: This study was designed to evaluate the effect of nitric oxide (NO) on the management of neonates with severe persistent pulmonary hypertension refractory... -
Federal
The MRC trial of assessment and management of older people in the community: objectives, design and interventions [ISRCTN23494848]
U.S. Department of Health & Human Services —
Background The benefit of regular multidimensional assessment of older people remains controversial. The majority of trials have been too small to produce adequate... -
Federal
Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I
U.S. Department of Health & Human Services —
Background Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share... -
Federal
Incomplete evidence: the inadequacy of databases in tracing published adverse drug reactions in clinical trials
U.S. Department of Health & Human Services —
Background We would expect information on adverse drug reactions in randomised clinical trials to be easily retrievable from specific searches of electronic... -
Federal
Are there fundamental deficiencies in the megatrial methodology?
U.S. Department of Health & Human Services —
Are there fundamental deficiencies in the megatrial methodology? -
Federal
The dynamics of venous return and response to hypervolemia in the toad,
U.S. Department of Health & Human Services —
Background Venous return from the posterior region of amphibians travels by either two renal portal veins to the kidney or a central abdominal vein that drains into... -
Federal
Expression of the C5a receptor (CD88) on granulocytes and monocytes in patients with severe sepsis
U.S. Department of Health & Human Services —
Introduction Treatment of patients with severe sepsis with agents antagonising the effects of C5a has been proposed based on beneficial effects in animal experiments... -
Federal
Resource use data by patient report or hospital records: Do they agree?
U.S. Department of Health & Human Services —
Background Economic evaluations alongside clinical trials are becoming increasingly common. Cost data are often collected through the use of postal questionnaires;... -
Federal
Bacterial discrimination by means of a universal array approach mediated by LDR (ligase detection reaction)
U.S. Department of Health & Human Services —
Background PCR amplification of bacterial 16S rRNA genes provides the most comprehensive and flexible means of sampling bacterial communities. Sequence analysis of... -
Federal
The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability
U.S. Department of Health & Human Services —
Background Bloom syndrome is a rare cancer-prone disorder in which the cells of affected persons have a high frequency of somatic mutation and genomic instability.... -
Federal
Prominent medical journals often provide insufficient information to assess the validity of studies with negative results
U.S. Department of Health & Human Services —
Background Physicians reading the medical literature attempt to determine whether research studies are valid. However, articles with negative results may not provide... -
Federal
Gender and HIV-associated pulmonary tuberculosis: presentation and outcome at one year after beginning antituberculosis treatment in Uganda
U.S. Department of Health & Human Services —
Background Tuberculosis is responsible for more female deaths around the earth than any other infectious disease. Reports have suggested that responses to...
2,009 datasets found