2,009 datasets found
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Federal
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation
U.S. Department of Health & Human Services —
Cytokines play a critical role in the normal development and function of the immune system. On the other hand, many rheumatologic diseases are characterized by poorly... -
Federal
Is there a clinically significant gender bias in post-myocardial infarction pharmacological management in the older (>60) population of a primary care practice?
U.S. Department of Health & Human Services —
Background Differences in the management of coronary artery disease between men and women have been reported in the literature. There are few studies of potential... -
Federal
The relationship between FV Leiden and pulmonary embolism
U.S. Department of Health & Human Services —
Pulmonary embolism (PE) is one of the leading causes of in-patient hospital deaths. As a consequence, the identification of hemostatic variables that could identify... -
Federal
Equipment review: Measurement of occlusion pressures in critically ill patients
U.S. Department of Health & Human Services —
Equipment review: Measurement of occlusion pressures in critically ill patients -
Federal
Long-term cultivation of colorectal carcinoma cells with anti-cancer drugs induces drug resistance and telomere elongation: an
U.S. Department of Health & Human Services —
Background The role of telomerase activation in the expression and/or maintenance of drug resistance is not clearly understood. Therefore, we investigated the... -
Federal
Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle
U.S. Department of Health & Human Services —
Background Versatile transgenic manipulation of skeletal muscle requires knowledge of the expression profiles of diverse promoter/enhancer elements in the... -
Federal
Staphylococcal peptidoglycans induce arthritis
U.S. Department of Health & Human Services —
Staphylococcus aureus is one of the most important pathogens in septic arthritis. To analyse the arthritogenic properties of staphylococcal peptidoglycan (PGN),... -
Federal
Links between complement deficiency and apoptosis
U.S. Department of Health & Human Services —
Deficiency in the classical pathway complement components displays a hierarchical association with the development of systemic lupus erythematosus (SLE). In addition,... -
Federal
USF2 inhibits C/EBP-mediated transcriptional regulation of the RIIβ subunit of cAMP-dependent protein kinase
U.S. Department of Health & Human Services —
Background Cyclic AMP-dependent protein kinase (PKA) plays a central role in regulation of energy metabolism. Upon stimulation of testicular Sertoli cells by follicle... -
Federal
Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate
U.S. Department of Health & Human Services —
Background Thiamine diphosphate (ThDP) is the active form of thiamine, and it serves as a cofactor for several enzymes, both cytosolic and mitochondrial. Isolated... -
Federal
Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach
U.S. Department of Health & Human Services —
Background The cockroach salivary gland consists of secretory acini with peripheral ion-transporting cells and central protein-producing cells, an extensive duct... -
Federal
The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs
U.S. Department of Health & Human Services —
Background Recent reports have raised concerns that postnatal steroids may cause neuro-developmental impairment in preterm infants. This systematic review was... -
Federal
Accuracy of responses from postal surveys about continuing medical education and information behavior: experiences from a survey among German diabetologists
U.S. Department of Health & Human Services —
Background Postal surveys are a popular instrument for studies about continuing medical education habits. But little is known about the accuracy of responses in such... -
Federal
Highly efficient genetic transduction of primary human synoviocytes with concentrated retroviral supernatant
U.S. Department of Health & Human Services —
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in... -
Federal
High affinity binding of proteins HMG1 and HMG2 to semicatenated DNA loops
U.S. Department of Health & Human Services —
Background Proteins HMG1 and HMG2 are two of the most abundant non histone proteins in the nucleus of mammalian cells, and contain a domain of homology with many... -
Federal
Do pediatric intensivists and radiologists concur on the interpretation of chest radiographs?
U.S. Department of Health & Human Services —
Background: Therapeutic decisions in the pediatric intensive care unit are made by pediatric intensivists (PI) based on their interpretation of chest radiographs... -
Federal
Ligamentous rupture of the ACL associated with dislocated fracture of the proximal tibial physis in a 12-year-old boy
U.S. Department of Health & Human Services —
Background Dislocated fracture of the proximal physeal plate of the tibia with or without metaphyseal fragment is rare in children. This unusual fracture classically... -
Federal
Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes
U.S. Department of Health & Human Services —
Background Lysosomes are acidic organelles that play multiple roles in various cellular oxidative activities such as the oxidative burst during cytotoxic killing. It... -
Federal
Association of mesenchymal cells and immunoglobulins with differentiating epithelial cells
U.S. Department of Health & Human Services —
Background Mesenchymal-epithelial interactions play an important role in the physiology and pathology of epithelial tissues. Mesenchymal cells either associate with... -
Federal
Development of an optimized interaction-mating protocol for large-scale yeast two-hybrid analyses
U.S. Department of Health & Human Services —
Background Protein-protein interactions have decisive roles in almost all aspects of the structural and functional organization of cells. But in spite of the...
2,009 datasets found