2,009 datasets found
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Federal
Functional group interactions of a 5-HT
U.S. Department of Health & Human Services —
Background Lerisetron, a competitive serotonin type 3 receptor (5-HT3R) antagonist, contains five functional groups capable of interacting with amino acids in the... -
Federal
A surrogate-based approach for post-genomic partner identification
U.S. Department of Health & Human Services —
Background Modern drug discovery is concerned with identification and validation of novel protein targets from among the 30,000 genes or more postulated to be present... -
Federal
Bone loss: Factors that regulate osteoclast differentiation - an update
U.S. Department of Health & Human Services —
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among... -
Federal
Independent predictors of breastfeeding intention in a disadvantaged population of pregnant women
U.S. Department of Health & Human Services —
Background Breastfeeding rates in Scotland are very low, particularly in the more disadvantaged areas. Despite a number of interventions to promote breastfeeding very... -
Federal
A novel link between the proteasome pathway and the signal transduction pathway of the Bone Morphogenetic Proteins (BMPs)
U.S. Department of Health & Human Services —
Background The intracellular signaling events of the Bone Morphogenetic Proteins (BMPs) involve the R-Smad family members Smad1, Smad5, Smad8 and the Co-Smad, Smad4.... -
Federal
Combined antibiotic and free radical trap treatment is effective at combating
U.S. Department of Health & Human Services —
Although early antibiotic treatment of patients with septic arthritis eradicates bacteria, joint destruction commonly results from the unregulated host inflammatory... -
Federal
What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis
U.S. Department of Health & Human Services —
The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the... -
Federal
PCR identification of
U.S. Department of Health & Human Services —
Trypanosoma (Herpetosoma) lewisi is a trypanosome of the sub-genus Herpetosoma (Stercoraria section), parasite of rats (Rattus rattus and Rattus norvegicus)... -
Federal
Anti-TNF-α therapy as a clinical intervention for periprosthetic osteolysis
U.S. Department of Health & Human Services —
Aseptic loosening of total joint arthroplastics due to periprosthetic osteolysis is a frequent cause of implant failure. The absence of clinical interventions to... -
Federal
Identification of the gene encoding Brain Cell Membrane Protein 1 (BCMP1), a putative four-transmembrane protein distantly related to the Peripheral Myelin Protein 22 / Epithelial Membrane Proteins and the Claudins
U.S. Department of Health & Human Services —
Background A partial cDNA clone from dog thyroid presenting a very significant similarity with an uncharacterized mouse EST sequence was isolated fortuitously. We... -
Federal
A combined in vitro / in vivo selection for polymerases with novel promoter specificities
U.S. Department of Health & Human Services —
Background The DNA-dependent RNA polymerase from T7 bacteriophage (T7 RNAP) has been extensively characterized, and like other phage RNA polymerases it is highly... -
Federal
Identification of four families of yCCR4- and Mg
U.S. Department of Health & Human Services —
Background The yeast yCCR4 factor belongs to the CCR4-NOT transcriptional regulatory complex, in which it interacts, through its leucine-rich repeat (LRR) motif with... -
Federal
Expression of interleukin-18 receptor in fibroblast-like synoviocytes
U.S. Department of Health & Human Services —
An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates... -
Federal
NF-kappaB in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction
U.S. Department of Health & Human Services —
The transcription factor NF-κB has been well recognized as a pivotal regulator of inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad... -
Federal
Molecular cloning and sequence analysis of hamster CENP-A cDNA
U.S. Department of Health & Human Services —
Background The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged... -
Federal
Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis
U.S. Department of Health & Human Services —
Purpose To report a case of atypical herpes simplex keratitis initially diagnosed as bacterial keratitis, in a contact lens wearer. Results Case report of an 18-year-... -
Federal
Noncoding RNA gene detection using comparative sequence analysis
U.S. Department of Health & Human Services —
Background Noncoding RNA genes produce transcripts that exert their function without ever producing proteins. Noncoding RNA gene sequences do not have strong... -
Federal
Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care
U.S. Department of Health & Human Services —
The respiratory effects of dexmedetomidine were retrospectively examined in 33 postsurgical patients involved in a randomised, placebo-controlled trial after... -
Federal
Immune modulation in the treatment of respiratory infection
U.S. Department of Health & Human Services —
The limitations of currently available treatment for severe respiratory infection are demonstrated by the relatively fixed mortality associated with these infections... -
Federal
Microscopy of bacterial translocation during small bowel obstruction and ischemia in vivo – a new animal model
U.S. Department of Health & Human Services —
Background Existing animal models provide only indirect information about the pathogenesis of infections caused by indigenous gastrointestinal microflora and the...
2,009 datasets found