2,009 datasets found
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Federal
Differential clinical efficacy of anti-CD4 monoclonal antibodies in rat adjuvant arthritis is paralleled by differential influence on NF-κB binding activity and TNF-α secretion of T cells
U.S. Department of Health & Human Services —
The aim of this study was to analyze the differential effects of three anti-CD4 monoclonal antibodies (mAbs) (with distinct epitope specifities) in the treatment of... -
Federal
Fusion of the
U.S. Department of Health & Human Services —
Background The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a... -
Federal
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
U.S. Department of Health & Human Services —
Background Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket.... -
Federal
Early inflammatory markers in elicitation of allergic contact dermatitis
U.S. Department of Health & Human Services —
Background Allergic Contact Dermatitis (ACD) is regarded as a T-cell-mediated delayed-type hypersensitivity reaction. We studied the kinetics of the expression of... -
Federal
Angiogenesis in the pathogenesis of inflammatory joint and lung diseases
U.S. Department of Health & Human Services —
This paper reviews hypotheses about roles of angiogenesis in the pathogenesis of inflammatory disease in two organs, the synovial joint and the lung.... -
Federal
Plasma proteins in a standardised skin mini-erosion (I): permeability changes as a function of time
U.S. Department of Health & Human Services —
Background A standardised technique using a suction-induced mini-erosion that allows serial sampling of dermal interstitial fluid (IF) for 5 to 6 days has been... -
Federal
Measurement of tracheal temperature is not a reliable index of total respiratory heat loss in mechanically ventilated patients
U.S. Department of Health & Human Services —
Background: Minimizing total respiratory heat loss is an important goal during mechanical ventilation. The aim of the present study was to evaluate whether changes in... -
Federal
Evaluation of thresholds for the detection of binding sites for regulatory proteins in
U.S. Department of Health & Human Services —
Background Sites in DNA that bind regulatory proteins can be detected computationally in various ways. Pattern discovery methods analyze collections of genes... -
Federal
Research Article: BMC Ecology
U.S. Department of Health & Human Services —
Background In spite of very low nutrient concentrations in its vicinity – both column and pore waters-, the Posidonia oceanica of the Revellata Bay displays high... -
Federal
A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region:
U.S. Department of Health & Human Services —
Background: Sodium bicarbonate cotransporter (NBC) genes encode proteins that execute coupled Na+ and HCO3- transport across epithelial cell membranes. We report the... -
Federal
Monoarticular antigen-induced arthritis leads to pronounced bilateral upregulation of the expression of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion neurons of rats
U.S. Department of Health & Human Services —
This study describes the upregulation of neurokinin 1 and bradykinin 2 receptors in dorsal root ganglion (DRG) neurons in the course of antigen-induced arthritis... -
Federal
MID1 and MID2 homo- and heterodimerise to tether the rapamycin-sensitive PP2A regulatory subunit, Alpha 4, to microtubules: implications for the clinical variability of X-linked Opitz GBBB syndrome and other developmental disorders
U.S. Department of Health & Human Services —
Background Patients with Opitz GBBB syndrome present with a variable array of developmental defects including craniofacial, cardiac, and genital anomalies. Mutations... -
Federal
Characterization of adjacent breast tumors using oligonucleotide microarrays
U.S. Department of Health & Human Services —
Background Current methodology often cannot distinguish second primary breast cancers from multifocal disease, a potentially important distinction for clinical... -
Federal
Factors regulating Hb F synthesis in thalassemic diseases
U.S. Department of Health & Human Services —
Background The thalassemic syndromes originate from mutations of the globin genes that cause, besides the characteristic clinical picture, also an increased Hb F... -
Federal
A successful pregnancy following SEM fine tuning of hormonal priming
U.S. Department of Health & Human Services —
Background Manipulation of the uterine epithelium utilising standard dose exogenous oestrogen (E2) and progesterone (P4) has been shown to achieve a mature secretory... -
Federal
Separate urinary bladder and prostate neurons in the central nervous system of the rat: simultaneous labeling with two immunohistochemically distinguishable pseudorabies viruses
U.S. Department of Health & Human Services —
Background This work examines the central nervous system distribution of virus-labeled neurons from the rat urinary bladder and the prostate simultaneously within the... -
Federal
Calcium-mediated transductive systems and functionally active gap junctions in astrocyte-like GL15 cells
U.S. Department of Health & Human Services —
Background It has been proposed that GL15, a human cell line derived from glioblastoma multiforme, is a possible astroglial-like cell model, based on the presence of... -
Federal
Molecular cloning of the rat proteinase-activated receptor 4 (PAR4)
U.S. Department of Health & Human Services —
Background The proteinase-activated receptor 4 (PAR4) is a G-protein-coupled receptor activated by proteases such as thrombin and trypsin. Although activation of PAR4... -
Federal
Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model
U.S. Department of Health & Human Services —
Background Gene transfer studies in primary T cells have suffered from the limitations of conventional viral transduction or transfection techniques. Replication-... -
Federal
Amyloid associated with elastin-staining laminar aggregates in the lungs of patients diagnosed with acute respiratory distress syndrome
U.S. Department of Health & Human Services —
Background The heterogeneity of conditions underlying respiratory distress, whether classified clinically as acute lung injury (ALI) or the more severe acute...
2,009 datasets found