2,009 datasets found
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Federal
How many replicates of arrays are required to detect gene expression changes in microarray experiments? A mixture model approach
U.S. Department of Health & Human Services —
Background It has been recognized that replicates of arrays (or spots) may be necessary for reliably detecting differentially expressed genes in microarray... -
Federal
Expression and localization of estrogen receptor-β in annulus cells of the human intervertebral disc and the mitogenic effect of 17-β-estradiol in vitro
U.S. Department of Health & Human Services —
Background Recent evidence suggests that estrogens exert effects in different tissues throughout the body, and that the estrogen receptor β (ERβ) may be important for... -
Federal
The role of statins as potential targets for bone formation
U.S. Department of Health & Human Services —
Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A reductase enzyme have recently been shown to stimulate bone formation in rodents both in vitro and in vivo. In... -
Federal
Research Article: Arthritis Research
U.S. Department of Health & Human Services —
Synovial fibroblasts (SFs) have become a major target for ex vivo gene transfer in rheumatoid arthritis (RA), but efficient transduction of RA-SFs still is a major... -
Federal
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors
U.S. Department of Health & Human Services —
Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial collagenases that degrade type II collagen in cartilage; this is a committed step in the... -
Federal
Post-transcriptional regulation of pro-inflammatory gene expression
U.S. Department of Health & Human Services —
The cytokine tumour necrosis factor (TNF)α is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in... -
Federal
Research Article: BMC Genetics
U.S. Department of Health & Human Services —
Background Blood group genotyping is increasingly utilized for prenatal diagnosis and after recent transfusions, but still lacks the specificity of serology. In... -
Federal
Modeling of failure mode in knee ligaments depending on the strain rate
U.S. Department of Health & Human Services —
Background The failure mechanism of the knee ligament (bone-ligament-bone complex) at different strain rates is an important subject in the biomechanics of the knee.... -
Federal
Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells
U.S. Department of Health & Human Services —
Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling... -
Federal
Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells
U.S. Department of Health & Human Services —
Background Dimerization is an important regulatory mechanism of single membrane-spanning receptors. For instance, activation of receptor protein-tyrosine kinases... -
Federal
Severe hypomagnesaemia with tetany following ESHAP protocol
U.S. Department of Health & Human Services —
Background One patient with B-cell Non-Hodgkin's Lymphoma developed severe hypomagnesaemia and tetany 15 days after the first course of treatment with ESHAP protocol.... -
Federal
Pharmacology of airway afferent nerve activity
U.S. Department of Health & Human Services —
Afferent nerves in the airways serve to regulate breathing pattern, cough, and airway autonomic neural tone. Pharmacologic agents that influence afferent nerve... -
Federal
Differences in time of virus appearance in the blood and virus-specific immune responses in intravenous and intrarectal primary SIV
U.S. Department of Health & Human Services —
Background HIV-I can be transmitted by intravenous inoculation of contaminated blood or blood product or sexually through mucosal surfaces. Here we performed a pilot... -
Federal
TheArthritis Researchnon-peer-review depository
U.S. Department of Health & Human Services —
As readers may already be aware, the NIH have declared a plan that invites any journal that wishes to participate to deposit non-peer-reviewed research into PubMed... -
Federal
Unpredicted spontaneous extrusion of a renal calculus in an adult male with spina bifida and paraplegia: report of a misdiagnosis. Measures to be taken to reduce urological errors in spinal cord injury patients
U.S. Department of Health & Human Services —
Background A delay in diagnosis or a misdiagnosis may occur in patients with spinal cord injury (SCI) or spinal bifida as typical symptoms of a clinical condition may... -
Federal
Intraoperative radiation therapy (IORT) for previously untreated malignant gliomas
U.S. Department of Health & Human Services —
Background Intraoperative radiation therapy (IORT) is one of the methods used to deliver a large single dose to the tumor tissue while reducing the exposure of normal... -
Federal
Beta-Adrenergic gene therapy for cardiovascular disease
U.S. Department of Health & Human Services —
Gene therapy using in vivo recombinant adenovirus-mediated gene transfer is an effective technique that offers great potential to improve existing drug treatments for... -
Federal
Combating Kinetoplastid diseases
U.S. Department of Health & Human Services —
Today's Kinetoplastida form a diverse order of flagellated protozoans that have evolved from an ancient lineage, rooted near the base of the eukaryotic tree. The... -
Federal
Distinct gene expression profiles of human type 1 and type 2 T helper cells
U.S. Department of Health & Human Services —
Background The development and activation of CD4+ helper T cell (Th) subsets with distinct patterns of unbalanced production of cytokines play an important part in... -
Federal
Timed sequential chemotherapy with concomitant Granulocyte Colony-Stimulating Factor for high-risk acute myelogenous leukemia: a single arm clinical trial
U.S. Department of Health & Human Services —
Background The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory...
2,009 datasets found