2,009 datasets found
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Federal
Importance of the TIMI frame count: implications for future trials
U.S. Department of Health & Human Services —
Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor... -
Federal
Insertion of a small peptide of six amino acids into the β7–β8 loop of the p51 subunit of HIV-1 reverse transcriptase perturbs the heterodimer and affects its activities
U.S. Department of Health & Human Services —
Background HIV-1 RT is a heterodimeric enzyme, comprising of the p66 and p51 subunits. Earlier, we have shown that the β7-β8 loop of p51 is a key structural element... -
Federal
Which treatment for low back pain? A factorial randomised controlled trial comparing intravenous analgesics with oral analgesics in the emergency department and a centrally acting muscle relaxant with placebo over three days [ISRCTN09719705]
U.S. Department of Health & Human Services —
Background About two thirds of adults suffer from backpain at some time during their life. In the emergency room many patients with acute back pain are treated with... -
Federal
Disagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study
U.S. Department of Health & Human Services —
Background Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal... -
Federal
A new way to rapidly create functional, fluorescent fusion proteins: random insertion of GFP with an
U.S. Department of Health & Human Services —
Background The jellyfish green fluorescent protein (GFP) can be inserted into the middle of another protein to produce a functional, fluorescent fusion protein.... -
Federal
Stable hepatitis C virus RNA detection by RT-PCR during four days storage
U.S. Department of Health & Human Services —
Background Suboptimal specimen processing and storage conditions of samples which contain hepatitis C virus (HCV) RNA may result in a decline of HCV RNA concentration... -
Federal
Enteral feeding in the critically ill: comparison between the supine and prone positions: a prospective crossover study in mechanically ventilated patients
U.S. Department of Health & Human Services —
Introduction Prone position is effective in mechanically ventilated patients to improve oxygenation. It is unknown if prone position affects gastric emptying and the... -
Federal
Chemokines and their role in airway hyper-reactivity
U.S. Department of Health & Human Services —
Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and... -
Federal
Structural model of nicotinic acetylcholine receptor isotypes bound to acetylcholine and nicotine
U.S. Department of Health & Human Services —
Background Nicotine is a psychoactive drug presenting a diverse array of biological activities, some positive, such as enhancement of cognitive performances, others... -
Federal
Factors associated with home death for individuals who receive home support services: a retrospective cohort study
U.S. Department of Health & Human Services —
Objectives To determine the factors associated with a home death among older adults who received palliative care nursing home services in the home. Methods The... -
Federal
Cross-species hybridisation of pig RNA to human nylon microarrays
U.S. Department of Health & Human Services —
Background The objective of this research was to investigate the reproducibility of cross-species microarray hybridisation. Comparisons between same- and cross-... -
Federal
The role of the Zn(II) binding domain in the mechanism of
U.S. Department of Health & Human Services —
Background Escherichia coli DNA topoisomerase I binds three Zn(II) with three tetracysteine motifs which, together with the 14 kDa C-terminal region, form a 30 kDa... -
Federal
High serum alkaline phosphatase levels, a study in 181 Thai adult hospitalized patients
U.S. Department of Health & Human Services —
Background Alkaline phosphatase (ALP) is an important enzyme mainly derived from the liver, bones and in lesser amounts from intestines, placenta, kidneys and... -
Federal
Genetic stabilization by p53 involves growth regulatory and repair pathways
U.S. Department of Health & Human Services —
p53 performs a plethora of activities, which are directed towards the maintenance of the genomic integrity and constitute its universal role as a tumor suppressor.... -
Federal
Message to complementary and alternative medicine: evidence is a better friend than power
U.S. Department of Health & Human Services —
Background Evidence-based medicine (EBM) is being embraced by an increasing number of practitioners and advocates of complementary and alternative medicine (CAM). A... -
Federal
Identifying older diabetic patients at risk of poor glycemic control
U.S. Department of Health & Human Services —
Background Optimal glycemic control prevents the onset of diabetes complications. Identifying diabetic patients at risk of poor glycemic control could help promoting... -
Federal
Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices
U.S. Department of Health & Human Services —
Background Recently a hyperthermic rat hippocampal slice model system has been used to investigate febrile seizure pathophysiology. Our previous data indicates that... -
Federal
PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics
U.S. Department of Health & Human Services —
Background It is generally assumed that the tissue exchange of antibiotics is flow limited (complete equilibration between the capillary and the tissue water). This... -
Federal
Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients
U.S. Department of Health & Human Services —
Background Red blood cell (RBC) transfusion is commonly used to increase oxygen transport in patients with sepsis. However it does not consistently increase oxygen... -
Federal
Articular cartilage and changes in arthritis: Noncollagenous proteins and proteoglycans in the extracellular matrix of cartilage
U.S. Department of Health & Human Services —
Cartilage contains numerous noncollagenous proteins in its extracellular matrix, including proteoglycans. At least 40 such molecules have been identified, differing...
2,009 datasets found