2,009 datasets found
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Federal
FOUNTAIN: A JAVA open-source package to assist large sequencing projects
U.S. Department of Health & Human Services —
Background Better automation, lower cost per reaction and a heightened interest in comparative genomics has led to a dramatic increase in DNA sequencing activities.... -
Federal
PKQuest: volatile solutes – application to enflurane, nitrous oxide, halothane, methoxyflurane and toluene pharmacokinetics
U.S. Department of Health & Human Services —
Background The application of physiologically based pharmacokinetic models (PBPK) to human studies has been limited by the lack of the detailed organ information that... -
Federal
Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthma
U.S. Department of Health & Human Services —
Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well... -
Federal
Arthritis Research: the move to publish research articles in full online only
U.S. Department of Health & Human Services —
WhenArthritis Researchwas launched in 1999 the publishers and ourselves took the innovative decision to make all primary research articles available to everyone for... -
Federal
Assessing the quality of reports of randomized trials in pediatric complementary and alternative medicine
U.S. Department of Health & Human Services —
Objective To evaluate the quality of reports of complementary and alternative medicine (CAM) randomized controlled trials (RCTs) in the pediatric population. We also... -
Federal
Is insulin an endogenous cardioprotector?
U.S. Department of Health & Human Services —
Stress hyperglycemia and diabetes mellitus with myocardial infarction are associated with increased risk for in-hospital mortality, congestive heart failure, or... -
Federal
The Proliferation REduction with Vascular ENergy Trial (PREVENT)
U.S. Department of Health & Human Services —
PREVENT was the first prospective, randomized placebo-controlled study of intracoronary beta radiotherapy with 32P. A total of 105 patients with de novo or restenotic... -
Federal
Richness of Colchic vegetation: comparison between refugia of south-western and East Asia
U.S. Department of Health & Human Services —
Background The Colchis is one of the species-rich refugia and a centre of biological diversity in western Eurasia. We analysed patterns of richness, endemism and... -
Federal
Effect of a homeopathic drug, Chelidonium, in amelioration of p-DAB induced hepatocarcinogenesis in mice
U.S. Department of Health & Human Services —
Background Crude extracts of Chelidonium majus, and also purified compounds derived from crude extracts of this plant, have been reported to exhibit anti-viral, anti-... -
Federal
Permutation-validated principal components analysis of microarray data
U.S. Department of Health & Human Services —
Background In microarray data analysis, the comparison of gene-expression profiles with respect to different conditions and the selection of biologically interesting... -
Federal
HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels
U.S. Department of Health & Human Services —
Background HIPK2 (homeodomain-interacting protein kinase 2) has been identified as a nuclear serine/threonine kinase. A central function of HIPK2 is repressing... -
Federal
Respiratory syncytial virus and TNFalpha induction of chemokine gene expression involves differential activation of Rel A and NF-kappaB1
U.S. Department of Health & Human Services —
Background Respiratory syncytial virus (RSV) infection of airway epithelial cells stimulates the expression and secretion of a variety of cytokines including the... -
Federal
The usefulness of information on HDL-cholesterol: potential pitfalls of conventional assumptions
U.S. Department of Health & Human Services —
Treatment decisions related to disease prevention are often based on two conventional and related assumptions. First, an intervention-induced change in a surrogate... -
Federal
Differential binding of chemokines to macrophages and neutrophils in the human inflamed synovium
U.S. Department of Health & Human Services —
In chronic inflammatory foci, such as the rheumatoid joint, there is enhanced recruitment of phagocytes from the blood into the tissues. Chemokines are strongly... -
Federal
Therapeutic angiogenesis for cardiovascular disease
U.S. Department of Health & Human Services —
The identification of angiogenic growth factors, such as vascular endothelial growth factor and fibroblast growth factor, has fueled interest in using such factors to... -
Federal
Debate: The slippery slope of surrogate outcomes
U.S. Department of Health & Human Services —
Surrogate outcomes are frequently used in cardiovascular disease research. A concern is that changes in surrogate markers may not reflect changes in disease outcomes.... -
Federal
High frequency oscillatory ventilation attenuates the activation of alveolar macrophages and neutrophils in lung injury
U.S. Department of Health & Human Services —
Background: Recent investigations have shown that leukocyte activation is involved in the pathogenesis of ventilator-associated lung injury. This study was designed... -
Federal
A randomised controlled trial of a patient based Diabetes recall and Management system: the DREAM trial: A study protocol [ISRCTN32042030]
U.S. Department of Health & Human Services —
Background Whilst there is broad agreement on what constitutes high quality health care for people with diabetes, there is little consensus on the most efficient way... -
Federal
A new non-linear normalization method for reducing variability in DNA microarray experiments
U.S. Department of Health & Human Services —
A simple and robust non-linear method is presented for normalization using array signal distribution analysis and cubic splines. Both the regression and spline-based... -
Federal
Exertional dyspnea as initial manifestation of Takayasu's arteritis – A case report and literature review
U.S. Department of Health & Human Services —
Background Takayasu's arteritis is a chronic systemic inflammatory disease that usually affects the aorta, its primary branches and occasionally the pulmonary and...
2,009 datasets found