63 datasets found
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Federal
Dynamic gene expression response to altered gravity in human T cells (parabolic flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Exposure of zebrafish larvae to 3g and 5g hyper gravity between 5-6 days post-fertilization.
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors, with a special emphasis on bone formation. For this... -
Federal
Effect of acute muscle unloading on soleus and gastrocnemius muscle gene expression
National Aeronautics and Space Administration —
Gene expression changes induced by acute skeletal muscle unloading which leads to physiological changes including muscle atrophy fibre-type switching and loss of... -
Federal
Effect of a 91 day long stay in weightlessness on the International Space Station on mouse skin physiology
National Aeronautics and Space Administration —
Comparative gene expression in skin between mice maintained in microgravity (0g) and normogravity (1g) environment. Six male C57Bl/J10 mice were housed for 91 days in... -
Federal
Transcriptomic analysis of spleens from mice subjected to chronic low-dose radiation hindlimb unloading or a combination of both
National Aeronautics and Space Administration —
The purpose of this study was to evaluate transcriptional changes in mouse spleens using a ground-based model for spaceflight. This model includes prolonged unloading... -
Federal
mRNA expression profile in DLD-1 and MOLT-4 cancer cell lines cultured under Microgravity
National Aeronautics and Space Administration —
DLD-1 and MOLT-4 cell lines were cultured in a Rotating cell culture system to simulate microgravity and mRNA expression profile was observed in comparison to Static... -
Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Characterization of Epigenetic Regulation in an Extraterrestrial Environment: The Arabidopsis Spaceflight Methylome [RNA-seq]
National Aeronautics and Space Administration —
When germinated and grown on-board the ISS (International Space Station) plant do not exhibit abnormal structures but they do have altered growth habits and this... -
Federal
Environmental and facility conditions promote singular gravity responses of transcriptome during Drosophila metamorphosis
National Aeronautics and Space Administration —
Genome-wide transcriptional profiling showed that reducing gravity levels in the International Space Station (ISS) causes important alterations in Drosophila gene... -
Federal
Murine TCR-beta repertoire sequencing
National Aeronautics and Space Administration —
The purpose of this project was to determine the effects of chronic exposure to unpredictable mild socio-environmental stressors during gestation on the TCR-beta... -
Federal
Dynamic gene expression response to altered gravity in human T cells (sounding rocket flight)
National Aeronautics and Space Administration —
We investigated differentially regulated genes in human Jurkat T lymphocytic cells in 20s and 5min microgravity and in hypergravity and compared expression profiles... -
Federal
Proton irradiation augments the reduction in tumor progression observed with advanced age
National Aeronautics and Space Administration —
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have... -
Federal
Muscle atrophy osteoporosis prevention in hibernating mammals
National Aeronautics and Space Administration —
Physical inactivity decreases the mechanical load on the skeleton which when prolonged leads to losses of muscle strength and bone mass in humans and most mammalian... -
Federal
A study of alterations DNA epigenetic modifiincations (5mC and 5hmC) influenced by simulated microgravity in human lymphoblastoid cells
National Aeronautics and Space Administration —
Here in this study we systematically examined the patterns of DNA methylation and hydroxy-methylation with its functional implications in gene regulation for the... -
Federal
Expression data from rice calli cultured with 2,4-D
National Aeronautics and Space Administration —
Four days old rice calli were selected to grow 324h under spaceflight controls 1g-flight controls and 1g-ground controls. We used microarrays to detail the global... -
Federal
Plasticity of the human IgM repertoire in response to a long-term spaceflight
National Aeronautics and Space Administration —
Immune dysregulation is among the main adverse outcomes of spaceflight. Despite its crucial role in host protection effects on the human antibody repertoire are... -
Federal
During development the Sku5 mutant roots engage different genes than wild type WS roots either on the ground or in spaceflight.
National Aeronautics and Space Administration —
The wild type WS plants and the Sku5 mutant plants in the WS background were germinated on ISS or on the ground and the gene expression profiles in roots at 4 days or... -
Federal
miRNA signature detection and countermeasures against HZE radiation exposure for tissue degeneration-Liver tissue
National Aeronautics and Space Administration —
Biological risks associated with space radiation and microgravity are major concerns for long-term space travel. Through a Systems Biology approach our previous NASA... -
Federal
Transcription profiling of Drosophila exposed to a levitation magnet for different lengths of time
National Aeronautics and Space Administration —
Drosophila samples were exposed to the levitation magnet inside a 25mm diameter tubes with 3 ml of yeast-based Drosophila food in the bottom and a chamber of only 5... -
Federal
Zebrafish larvae submitted to simulated microgravity on a clinostat (CLINO) at 5dpf for one day
National Aeronautics and Space Administration —
The general objective of the study was to determine modulation of gene expression by environmental factors specifically simulation of microgravity with a special...
63 datasets found