2,009 datasets found
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Federal
Superantigen antagonist peptides
U.S. Department of Health & Human Services —
The production of superantigenic exotoxins by Gram positive bacteria underlies the pathology of toxic shock syndrome. Future treatment strategies for superantigen-... -
Federal
PKQuest: measurement of intestinal absorption and first pass metabolism – application to human ethanol pharmacokinetics
U.S. Department of Health & Human Services —
Background PKQuest, a new physiologically based pharmacokinetic (PBPK) program, is applied to human ethanol data. The classical definition of first pass metabolism... -
Federal
Mutant Rab24 GTPase is targeted to nuclear inclusions
U.S. Department of Health & Human Services —
Background Members of the Rab GTPase family regulate intracellular protein trafficking, but the specific function of Rab24 remains unknown. Several attributes... -
Federal
Fibroblast biology: Development and differentiation of synovial fibroblasts in arthritis
U.S. Department of Health & Human Services —
Synovial fibroblasts occur as two phenotypes - intimal and subintimal. The specialised intimal phenotype includes expression of uridine diphosphoglucose dehydrogenase... -
Federal
A study of cytokeratin 20 immunostaining in the urothelium of neuropathic bladder of patients with spinal cord injury
U.S. Department of Health & Human Services —
Background Normal urothelium is characterised by terminally differentiated superficial cells, which express cytokeratin 20 in the cytoplasm. In contrast, cultured... -
Federal
The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor
U.S. Department of Health & Human Services —
Background Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with... -
Federal
Th2 cytokines and asthma — Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
U.S. Department of Health & Human Services —
Interleukin-4 (IL-4) mediates important pro-inflammatory functions in asthma including induction of the IgE isotype switch, expression of vascular cell adhesion... -
Federal
Collection of corneal impression cytology directly on a sterile glass slide for the detection of viral antigen: An inexpensive and simple technique for the diagnosis of HSV epithelial keratitis – A pilot study
U.S. Department of Health & Human Services —
Background Herpes simplex keratitis (HSK) is a sight threatening ocular infection and occurs worldwide. A prompt laboratory diagnosis is often very useful.... -
Federal
Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes
U.S. Department of Health & Human Services —
Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three... -
Federal
Genetic epidemiology: Approaches to the genetic analysis of rheumatoid arthritis
U.S. Department of Health & Human Services —
The basis of susceptibility to rheumatoid arthritis (RA) is complex, comprising genetic and environmental susceptibility factors. We have reviewed the available... -
Federal
Lack of agreement between tonometric and gastric juice partial carbon dioxide tension
U.S. Department of Health & Human Services —
Our goal was to compare measurement of tonometered saline and gastric juice partial carbon dioxide tension (PCO2). In this prospective observational study, 112 pairs... -
Federal
Gastroenteritis outbreaks associated with Norwalk-like viruses and their investigation by nested RT-PCR
U.S. Department of Health & Human Services —
Background Norwalk-like viruses are the most common cause of gastroenteritis outbreaks and sporadic cases of vomiting and diarrhoea. In healthy individuals infection... -
Federal
Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats
U.S. Department of Health & Human Services —
Background We are investigating a double transgenic rat (dTGR) model, in which rats transgenic for the human angiotensinogen and renin genes are crossed. These rats... -
Federal
Measuring access to effective care among elderly medicare enrollees in managed and fee-for-service care: a retrospective cohort study
U.S. Department of Health & Human Services —
Background Our aim was to compare access to effective care among elderly Medicare patients in a Staff Model and Group Model HMO and in Fee-for-Service (FFS) care.... -
Federal
Identification of two
U.S. Department of Health & Human Services —
Background The ability of Mycobacterium tuberculosis to survive and replicate in macrophages is crucial for the mycobacterium's ability to infect the host and cause... -
Federal
Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays
U.S. Department of Health & Human Services —
A cell-culture model was used to establish a profile of gene expression during the effector phase of ceramide-mediated cell death. Of the 239 genes that met the... -
Federal
Receptor protein tyrosine kinase EphB4 is up-regulated in colon cancer
U.S. Department of Health & Human Services —
Background We have used commercially available cDNA arrays to identify EphB4 as a gene that is up-regulated in colon cancer tissue when compared with matched normal... -
Federal
Identification of candidate downstream genes for the homeodomain transcription factor Labial in
U.S. Department of Health & Human Services —
Background: Homeotic genes are key developmental regulators that are highly conserved throughout evolution. Their encoded homeoproteins function as transcription... -
Federal
Impact of nosocomial pneumonia on the outcome of mechanically-ventilated patients
U.S. Department of Health & Human Services —
Background: Nosocomial pneumonia (NP) is a common complication in mechanically-ventilated patients and is considered to be one of the most common causes of morbidity... -
Federal
Debate: What constitutes 'terminality' and how does it relate to a Living Will?
U.S. Department of Health & Human Services —
A moribund and debilitated patient arrives in an emergency department and is placed on life support systems. Subsequently it is determined that she has a 'living...
2,009 datasets found