2,009 datasets found
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Federal
Lateral gene transfer and parallel evolution in the history of glutathione biosynthesis genes
U.S. Department of Health & Human Services —
Background Glutathione is found primarily in eukaryotes and in Gram-negative bacteria. It has been proposed that eukaryotes acquired the genes for glutathione... -
Federal
Evaluation of normalization procedures for oligonucleotide array data based on spiked cRNA controls
U.S. Department of Health & Human Services —
Background Affymetrix oligonucleotide arrays simultaneously measure the abundances of thousands of mRNAs in biological samples. Comparability of array results is... -
Federal
Cytosolic acidification as a signal mediating hyperosmotic stress responses in
U.S. Department of Health & Human Services —
Background Dictyostelium cells exhibit an unusual response to hyperosmolarity that is distinct from the response in other organisms investigated: instead of... -
Federal
The role of X-chromosome inactivation in female predispositionto autoimmunity
U.S. Department of Health & Human Services —
The role of X-chromosome inactivation in female predispositionto autoimmunity -
Federal
Molecular genetics and structural genomics of the human protein kinase C gene module
U.S. Department of Health & Human Services —
Background Protein kinase C (PKC) has become a major focus among cell biologists interested in second-messenger signal transduction and much has been learned about... -
Federal
Efficacy and adverse effects of intravenous lignocaine therapy in fibromyalgia syndrome
U.S. Department of Health & Human Services —
Background To investigate the effects of intravenous lignocaine infusions (IV lignocaine) in fibromyalgia. Methods Prospective study of the adverse effects of IV... -
Federal
Auto-protective redox buffering systems in stimulated macrophages
U.S. Department of Health & Human Services —
Background Macrophages, upon encounter with micro-organisms or stimulated by cytokines, produce various effector molecules aimed at destroying the foreign agents and... -
Federal
Expression of p53, inducible nitric oxide synthase and vascular endothelial growth factor in gastric precancerous and cancerous lesions: correlation with clinical features
U.S. Department of Health & Human Services —
Background The growth and metastasis of tumors depend on the development of an adequate blood supply via angiogenesis. Recent studies indicate that the inducible... -
Federal
Statins as modulators of bone formation
U.S. Department of Health & Human Services —
The use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) to reduce serum cholesterol is well described. However, the recent finding that... -
Federal
Assessment of Equine Autoimmune Thrombocytopenia (EAT) by flow cytometry
U.S. Department of Health & Human Services —
Rationale Thrombocytopenia is a platelet associated process that occurs in human and animals as result of i) decreased production; ii) increased utilization; iii)... -
Federal
Mast cell activation and its relation to proinflammatory cytokine production in the rheumatoid lesion
U.S. Department of Health & Human Services —
Mast cell (MC) activation in the rheumatoid lesion provides numerous mediators that contribute to inflammatory and degradative processes, especially at sites of... -
Federal
Percutaneous treatment of chronic MRSA osteomyelitis with a novel plant-derived antiseptic
U.S. Department of Health & Human Services —
Background Antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE, are an increasing... -
Federal
The velocity of ultrasound in human primary melanoma tissue - implications for the clinical use of high resolution sonography
U.S. Department of Health & Human Services —
Background Ultrasonography with 20 MHz frequency can be used to estimate tumour thickness preoperatively in malignant melanoma (MM) of the skin. The vertical invasion... -
Federal
Comments on ALLHAT and doxazosin
U.S. Department of Health & Human Services —
This commentary has two purposes: to summarize the rationale, design and initial results of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack... -
Federal
Gene trapping identifies transiently induced survival genes during programmed cell death
U.S. Department of Health & Human Services —
Background The existence of a constitutively expressed machinery for death in individual cells has led to the notion that survival factors repress this machinery and,... -
Federal
Carpal alignment in distal radial fractures
U.S. Department of Health & Human Services —
Background Carpal malalignment following the malunited distal radial fracture is described to develop as an adaptation to realign the hand to the malunion. It worsens... -
Federal
Cytokines as new treatment targets in chronic heart failure
U.S. Department of Health & Human Services —
Inflammatory cytokines may negatively influence contractility and contribute to the remodelling process in the failing myocardium. Traditional cardiovascular drugs... -
Federal
Immune ablation and stem-cell therapy in autoimmune disease: Immunological reconstitution after high-dose immunosuppression and haematopoietic stem-cell transplantation
U.S. Department of Health & Human Services —
Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human... -
Federal
Age-dependent changes in 24-hour rhythms of catecholamine content and turnover in hypothalamus, corpus striatum and pituitary gland of rats injected with Freund's adjuvant
U.S. Department of Health & Human Services —
Background Little information is available on the circadian sequela of an immune challenge in the brain of aged rats. To assess them, we studied 24-hour rhythms in... -
Federal
Neurotrophins in bronchial asthma
U.S. Department of Health & Human Services —
Allergic bronchial asthma (BA) is characterized by chronic airway inflammation, development of airway hyperreactivity and recurrent reversible airway obstruction....
2,009 datasets found