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Federal
Biventricular pacing in heart failure: update on results from clinical trials
U.S. Department of Health & Human Services —
Biventricular pacing or resynchronisation therapy is a non-pharmacological therapy for patients with chronic heart failure. Since being originally described in 1994,... -
Federal
Hypothesis to explain poor outcomes in the ALLHAT and V-HeFT trials: decreased expression of heat shock proteins
U.S. Department of Health & Human Services —
An explanation for the higher incidence of cardiovascular disease and heart failure in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial... -
Federal
Diuretics: again the first step in the treatment of most patients with hypertension
U.S. Department of Health & Human Services —
The results and interpretations of the most recent controlled clinical trials on antihypertensive drugs have fuelled the debate about the drug that should be used to... -
Federal
Use of diffusion and perfusion magnetic resonance imaging as a tool in acute stroke clinical trials
U.S. Department of Health & Human Services —
In light of the slow progress in developing effective therapies for ischemic stroke, magnetic resonance imaging techniques have emerged as new tools in stroke... -
Federal
Research Article: Current Controlled Trials in Cardiovascular Medicine
U.S. Department of Health & Human Services —
Research Article: Current Controlled Trials in Cardiovascular Medicine -
Federal
Fundamental deficiencies in the megatrial methodology
U.S. Department of Health & Human Services —
The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects.... -
Federal
Debate: A subversive view of subsets - a dissident clinician's opinion
U.S. Department of Health & Human Services —
Clinical trialists and statisticians are very wary of subgroup analysis, for good reasons. Clinicians have to deal with situations in which subgroups of patients...