288 datasets found
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Federal
Response of human lymphoblastoid cells to HZE (iron ions) or gamma-rays
National Aeronautics and Space Administration —
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiated cells with cells exposed 24 hours previously to 1.67 Gy HZE (1 GeV/amu iron ions... -
Federal
SpaceX Inspiration4 Dragon Capsule Metagenomic and Metatranscriptomic Microbial Swabs
National Aeronautics and Space Administration —
The SpaceX Inspiration4 mission was a 3-day mission with four private astronauts to low Earth orbit that occurred in September 2021. The crew collected biospecimen... -
Federal
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures (Elevated Plus Maze, Novel Object Recognition, Open Field, Radial Arm Water Maze, and Three Chamber Social Isolation/Interaction)
National Aeronautics and Space Administration —
In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle... -
Federal
Response of Staphylococcus aureus physiology and Agr quorum sensing to low shear modelled microgravity
National Aeronautics and Space Administration —
Staphylococcus aureus is commonly isolated from astronauts returning from spaceflight missions. Previous analysis of BRIC-23 omics data generated from S. aureus low... -
Federal
Effects of 32 Days Aboard the ISS on Gastrocnemius Tendon Nanomechanics (Gastrocnemius tendon, RR-1 and Atomic Force Microscopy)
National Aeronautics and Space Administration —
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to... -
Federal
Transcriptional profiling of soleus muscle from mice flown on the RR-23 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-23 mission (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function of... -
Federal
Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats
National Aeronautics and Space Administration —
Effects and interactions between different spaceflight stressors are expected to be experienced by crew on missions when exposed to microgravity and galactic cosmic... -
Federal
Transcriptional and proteomic response of Pseudomonas aeruginosa PAO1 to spaceflight conditions involves Hfq regulation and reveals a role for oxygen
National Aeronautics and Space Administration —
This study describes the transcriptional response of P. aeruginosa PAO1 to low-Earth orbit environmental conditions. Our aim was to assess whether the microgravity... -
Federal
Response of human lymphoblastoid cells to activated medium
National Aeronautics and Space Administration —
Transcriptional profiling of human lymphoblastoid TK6 cells comparing mock irradiaed cells resuspended in fresh untreated RPMI 1640 medium with cells resuspended in... -
Federal
Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection
National Aeronautics and Space Administration —
To reveal outcomes of microgravity on molecular processes within the cellular environment we have employed a mass-spectrometry based proteomics approach. Proteomics... -
Federal
Long-read sequencing reveals increased occurrence of genomic variants and adenosine methylation in Bacillus pumilus SAFR-032 after long-duration flight exposure onboard the International Space Station
National Aeronautics and Space Administration —
Bacillus pumilus SAFR-032, an endospore-forming bacterial strain, was investigated to determine its methylation pattern (methylome) change, compared to ground... -
Federal
Rodent Research-1 (RR1) National Lab Validation Flight: Mouse liver transcriptomic, proteomic, epigenomic and histology data
National Aeronautics and Space Administration —
The Rodent Reasearch-1 National Lab (RR-1 CASIS) experiment was performed to study the effect of microgravity on muscle wasting. RNA, DNA, and protein were purified... -
Federal
Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model
National Aeronautics and Space Administration —
While it has been shown that astronauts suffer immune disorders after spaceflight, the underlying causes are still poorly understood and there are many variables to... -
Federal
Transcriptional profiling of spleens from mice flown on the RR-23 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-23 missions (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function... -
Federal
The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures (Flow Cytometry, Microglia)
National Aeronautics and Space Administration —
In the coming decade, astronauts will travel back to the moon in preparation for future Mars missions. Exposure to galactic cosmic radiation (GCR) is a major obstacle... -
Federal
Bulk RNA sequencing and single nuclei transcriptomics and epigenomics of brain tissue from mice flown on the RRRM-2 mission
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes
National Aeronautics and Space Administration —
We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53 null mammary tissue to sham or irradiated hosts. Gene... -
Federal
During development, the Sku6 mutant roots engage different genes than wild type Col-0 roots, either on the ground or in spaceflight.
National Aeronautics and Space Administration —
The wild type Col-0 plants and the Sku-6 mutant plants of the Col-0 background were germinated on ISS or on the ground and the gene expression profiles in roots at 4... -
Federal
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster (Immunohistochemistry)
National Aeronautics and Space Administration —
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in... -
Federal
STS-135: Mouse Liver Transcriptomics using RNA-Seq
National Aeronautics and Space Administration —
Female C57BL/6CR mice were flown onboard STS-135 for 13 days and returned to Earth for analysis. Livers were collected within 3-4 hours of landing and snap frozen in...
288 datasets found