288 datasets found
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Federal
Microbial Observatory (ISS-MO): Antimicrobial resistance genes
National Aeronautics and Space Administration —
The environmental samples were collected with the polyester wipes from eight different locations in the International Space Station (ISS) during two consecutive... -
Federal
RNA-Seq analysis identifies potential modulators of gravity response in Ceratopteris spores: Evidence for modulation by calcium pumps and apyrase activity
National Aeronautics and Space Administration —
Gravity regulates the magnitude and direction of a trans-cell calcium current in germinating spores of Ceratopteris richardii. Blocking this current with nifedipine... -
Federal
Delayed Cardiomyocyte Response to Total Body Particle Radiation Exposure - Identification of Regulatory Gene Network [iron]
National Aeronautics and Space Administration —
We examined molecular responses using transcriptome profiling in isolated left ventricular murine cardiomyocytes to 90 cGy, 1 GeV proton (1H) and 15 cGy, 1... -
Federal
Response of mammary tissue to high-LET HZE particle (Silicon ions) radiation or low-LET gamma-rays
National Aeronautics and Space Administration —
Transcriptional profiling of mammary tissue irradiated at 10 weeks of age with either 100 cGy sparsely ionizing gamma-rays, or 10 cGy or 30 cGy densely ionizing... -
Federal
Candida albicans response to spaceflight (NASA STS-115)
National Aeronautics and Space Administration —
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans,... -
Federal
Transcriptional profiling of heart tissue from mice flown on the RRRM-2 mission
National Aeronautics and Space Administration —
In the Rodent Research Reference Mission (RRRM-2), forty female C57BL/6NTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Femur - microCT, three-point bending, histomorphometry)
National Aeronautics and Space Administration —
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of... -
Federal
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Tibia - pQCT)
National Aeronautics and Space Administration —
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of... -
Federal
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress related damage in the murine retina (RR-9)
National Aeronautics and Space Administration —
Extended spaceflight has been shown to adversely affect astronaut visual acuity. The purpose of this study was to determine whether spaceflight alters gene expression... -
Federal
Transcriptional profiling of thymus from mice flown on the RR-23 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-23 missions (RR-23) was to better understand the effects of spaceflight on the eyes, specifically on the structure and function... -
Federal
Elevated plus-maze performance of Fischer-344 rats as a function of age and of exposure to 56Fe particles
National Aeronautics and Space Administration —
The aging process is characterized by a series of changes in neurochemical functioning and in motor and cognitive performance. In addition to changes in... -
Federal
Evaluation of in vitro macrophage differentiation during space flight
National Aeronautics and Space Administration —
We differentiated mouse bone marrow cells in the presence of recombinant macrophage colony stimulating (rM-CSF) factor for 14 days during the flight of space shuttle... -
Federal
Quantifying Cancellous Bone Structural Changes in Microgravity: Axial Skeleton Results from the RR-1 Mission
National Aeronautics and Space Administration —
Objective of this study was to further validate bone degradation in microgravity as site-specific and preferential to weight bearing bone. An objective of this study... -
Federal
Bulk RNA sequencing and single nuclei transcriptomics and epigenomics of brain tissue from mice flown on the RR-10 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-10 mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue... -
Federal
Transcriptional profiling of colon from mice flown on the RR-10 mission
National Aeronautics and Space Administration —
The objective of the Rodent Research-10 mission (RR-10) was to investigate how spaceflight affects the cellular and molecular mechanisms of normal bone tissue... -
Federal
Metagenome profiling of feces from mice flown on the RRRM-1 mission
National Aeronautics and Space Administration —
In Rodent Research Reference Mission-1 (RRRM-1), forty female BALB/cAnNTac mice were flown on the International Space Station. To assess differences in outcomes due... -
Federal
Transcription profiling of S. cerevisiae cultures grown under low shear-modeled microgravity
National Aeronautics and Space Administration —
The goal of this study was to assess whether low shear-modeled microgravity (LSMMG) affects yeast genomic expression patterns using the powerful tool of whole genome... -
Federal
Transcription profiling of rat keratinocytes exposed to a 56Fe ion beam
National Aeronautics and Space Administration —
The purpose of the present work was to examine gene expression patterns in a rat keratinocyte line exposed to a 56Fe ion beam Experiment Overall Design: The cells... -
Federal
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats (Tibia; pQCT)
National Aeronautics and Space Administration —
Gonadal hormones, such as testosterone and estradiol, modulate muscle size and strength in males and females. However, the influence of sex hormones on muscle...
288 datasets found