124 datasets found
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Federal
Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
National Aeronautics and Space Administration —
With extended stays aboard the International Space Station (ISS) becoming commonplace there is a need to better understand the effects of microgravity on cardiac... -
Federal
RNA-Seq transcriptome profiling of soleus from adult and aged mice following disuse muscle atrophy and recovery
National Aeronautics and Space Administration —
Rodent hind limb unloading was used as a model for reduced muscle activity and eventual atrophy. After a 10 day period of unloading mice in this study were xe2 x80... -
Federal
Spatially resolved transcriptional analysis of hearts from mice flown on the RR-3 mission
National Aeronautics and Space Administration —
The Rodent Research-3 (RR-3) mission was sponsored by the pharmaceutical company Eli Lilly and Co. and the Center for the Advancement of Science in Space to study the... -
Federal
Temporal dynamics of the gut microbiota in people sharing a confined environment a 520-day ground-based space simulation MARS500
National Aeronautics and Space Administration —
The MARS500 project the longest ground-based space simulation ever provided us with a unique opportunity to trace the crew microbiota over 520 days of isolated... -
Federal
Efficient Identification of Multiple Pathways: RNA-Seq Analysis of Livers from 56Fe Ion Irradiated Mice
National Aeronautics and Space Administration —
Background: mRNA interactions with each other and other signaling molecules define different biological pathways and functions. Researchers have been investigating... -
Federal
Transcriptomic analysis of skin from mice subjected to chronic low-dose radiation hindlimb unloading or a combination of both
National Aeronautics and Space Administration —
The purpose of this study was to evaluate transcriptional changes in mouse skin using a ground-based model for spaceflight. This model includes prolonged unloading... -
Federal
Expression Data from International C. elegans Experiment 1st (ICE-FIRST)
National Aeronautics and Space Administration —
The effect of microgravity on gene expression in C.elegans was comprehensively analysed by DNA microarray (Agilent). Overall design: Mix staged C. elegans N2 was... -
Federal
Rodent Research-1 (RR1) National Lab Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data
National Aeronautics and Space Administration —
The Rodent Reasearch-1 National Lab (RR-1 CASIS) experiment was performed to study the effect of microgravity on muscle wasting. RNA DNA and protein were purified... -
Federal
Synergistic effects of space radiation and microgravity (miRNA WT and ced-1 mutant)
National Aeronautics and Space Administration —
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still... -
Federal
Mouse femur LC-MSMS upon weightlessness
National Aeronautics and Space Administration —
Bone loss and immune dysregulation are among the main adverse outcomes of spaceflight challenging astronaut xe2 x80 x99s health and safety. However consequences on B... -
Federal
Low dose (0.04 Gy) irradiation (LDR) and hindlimb unloading (HLU) microgravity in mice: brain transcriptomic and epigenomic data
National Aeronautics and Space Administration —
The purpose of the present study was to evaluate damage in brain and eye in a ground-based model for spaceflight which includes prolonged unloading and low-dose... -
Federal
Multi-omic investigations of mouse liver subjected to simulated spaceflight freezing and storage protocols
National Aeronautics and Space Administration —
This study compares standard laboratory protocols for tissue freezing and storage with a simulation of the delayed processing of liver specimens and long-term storage... -
Federal
Whole genome sequencing and assembly of Eukaryotic microbes isolated from ISS environmental surface Kirovograd region soil Chernobyl Nuclear Power Plant and Chernobyl Exclusion Zone
National Aeronautics and Space Administration —
The whole-genome sequences of eight fungal strains that were selected for exposure to microgravity at the International Space Station are presented here. These... -
Federal
Rodent Research-1 (RR1) NASA Validation Flight: Mouse liver transcriptomic proteomic and epigenomic data
National Aeronautics and Space Administration —
RR-1 is a validation flight to evaluate the hardware operational and science capabilities of the Rodent Research Project on the ISS. RNA DNA and protein were purified... -
Federal
Synergistic effects of microgravity and space radiation (Nimblegen)
National Aeronautics and Space Administration —
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still... -
Federal
Synergistic effects of microgravity and space radiation (Nimblegen)
National Aeronautics and Space Administration —
Space radiations and microgravity both could cause DNA damage in cells but the effects of microgravity on DNA damage response to space radiations are still... -
Federal
Whole genome sequencing and assembly of Eukaryotic microbes isolated from ISS environmental surface Kirovograd region soil Chernobyl Nuclear Power Plant and Chernobyl Exclusion Zone
National Aeronautics and Space Administration —
The whole-genome sequences of eight fungal strains that were selected for exposure to microgravity at the International Space Station are presented here. These... -
Federal
Genes Required for Survival in Microgravity Revealed by Genome-Wide Yeast Deletion Collections Cultured during Spaceflight
National Aeronautics and Space Administration —
Spaceflight is a unique environment with profound effects on biological systems including tissue redistribution and musculoskeletal stresses. However the more subtle... -
Federal
Effects of 21 days of bedrest on human skeletal muscle gene expression
National Aeronautics and Space Administration —
The present study concerns the effects of 21 days of sustained recumbence (bedrest) on skeletal muscle gene expression. 14 male subjects participated in normoxic... -
Federal
Analysis of dust samples from the Russian part of the ISS
National Aeronautics and Space Administration —
Our study focuses on the hardiest microorganisms inhabiting the ISS in order to assess their diversity and capabilities to resist certain stresses. We specifically...
124 datasets found